Anti-inflammatory activity of furosemide and spironolactone

Two diuretics - furosemide and spironolactone - were investigated for anti-inflammatory activity in two models of inflammation, namely, exudative phase (carrageenin-induced rat hind paw oedema) and proliferative phase (cotton pellet-induced granuloma in mice). Phe-nylbutazone, a non steroidal anti-inf lam-mator agent was used as a standard drug for comparison. In both the models of inflammation, furosemide showed statistically significant anti-inflammatory activity. Spironolactone, however, failed to exhibit significant anti-inflammatory activity in the model for acute inflammation though it was very effective in chronic inflammation