BACKGROUND: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates and significance of this are ill-defined. METHODS: Patients were assessed before and after their usual morning L-dopa dose, using the MDS Unified PD Rating Scale Part 3 (MDS UPDRS 3), and rated as definite responders (≥24.5% improvement) or limited responders (<24.5%). RESULTS: 1007 cases, mean age 66.1 years (SD 9.1) at diagnosis, were assessed 3.4 (SD 0.9) years after diagnosis. The L-dopa response was definite in 614 cases (61.0%), median reduction in MDS UPDRS 3 scores was 42.0%, (IQR 33.3, 53.1), and was limited in 393 cases (39.0%), median reduction in MDS UPDRS 3 scores 11.5% (IQR 4.3, 18.2). Definite responders were younger (66.3 years ...
Objectives: The authors investigated whether preprogramming (Bereitschaftspotential, BP) and control...
BACKGROUND: The clinical diagnosis of Parkinson\u27s disease (PD) requires the presence of parkinson...
BackgroundThe levodopa challenge test is routinely used in Parkinson disease (PD) to determine a pat...
BACKGROUND: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates an...
BACKGROUND: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates an...
L-dopa is the most commonly prescribed drug for the treatment of Parkinson’s disease (PD). Most pati...
Background: It is unclear to which degree Levodopa (L-dopa) remains effective also in the late stage...
BACKGROUND: Response fluctuations and dyskinesias develop during the use of both levodopa (LD) and d...
INTRODUCTION: It is important to understand how the rate of motor progression in PD relates to dopam...
Background: A good response to levodopa is a key feature of Parkinson's disease (PD), and a poor r...
BACKGROUND:Neuronal loss and dopamine depletion alter motor signal processing between cortical motor...
© 2019 Elsevier Ltd. All rights reserved.Levodopa (l-dopa) remains the gold-standard of Parkinson's ...
Background A good response to levodopa is a key feature of Parkinson's disease (PD), and a poor resp...
Background: Differential diagnosis between Parkinson's disease (PD) and atypical parkinsonisms (APs)...
International audienceBackground: Dopamine responsiveness (dopa-sensitivity) is an important paramet...
Objectives: The authors investigated whether preprogramming (Bereitschaftspotential, BP) and control...
BACKGROUND: The clinical diagnosis of Parkinson\u27s disease (PD) requires the presence of parkinson...
BackgroundThe levodopa challenge test is routinely used in Parkinson disease (PD) to determine a pat...
BACKGROUND: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates an...
BACKGROUND: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates an...
L-dopa is the most commonly prescribed drug for the treatment of Parkinson’s disease (PD). Most pati...
Background: It is unclear to which degree Levodopa (L-dopa) remains effective also in the late stage...
BACKGROUND: Response fluctuations and dyskinesias develop during the use of both levodopa (LD) and d...
INTRODUCTION: It is important to understand how the rate of motor progression in PD relates to dopam...
Background: A good response to levodopa is a key feature of Parkinson's disease (PD), and a poor r...
BACKGROUND:Neuronal loss and dopamine depletion alter motor signal processing between cortical motor...
© 2019 Elsevier Ltd. All rights reserved.Levodopa (l-dopa) remains the gold-standard of Parkinson's ...
Background A good response to levodopa is a key feature of Parkinson's disease (PD), and a poor resp...
Background: Differential diagnosis between Parkinson's disease (PD) and atypical parkinsonisms (APs)...
International audienceBackground: Dopamine responsiveness (dopa-sensitivity) is an important paramet...
Objectives: The authors investigated whether preprogramming (Bereitschaftspotential, BP) and control...
BACKGROUND: The clinical diagnosis of Parkinson\u27s disease (PD) requires the presence of parkinson...
BackgroundThe levodopa challenge test is routinely used in Parkinson disease (PD) to determine a pat...