Deficiency in Sperm–Egg Protein Interaction as a Major Cause of Fertilization Failure

Complete elucidation of fertilization process at molecular level is one of the unresolved challenges in sexual reproduction studies, and understanding the molecular mechanism is crucial in overcoming difficulties in infertility and unsuccessful in vitro fertilization. Sperm–oocyte interaction is one of the most remarkable events in fertilization process, and deficiency in protein–protein interactions which mediate this interaction is a major cause of unexplained infertility. Due to detection of how the various defects of sperm–oocyte interaction can affect fertilization failure, different experimental methods have been applied. This review summarizes the current understanding of sperm–egg interaction mechanism during fertilization and also accumulates the different types of sperm–egg interaction abnormalities and their association with infertility. Several detection approaches regarding sperm–egg protein interactions and the associated defects are reviewed in this paper