Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter
- Peerlinck, Inge
- Merron, Andrew
- Baril, Patrick
- Conchon, Sophie
- Martin-Duque, Pilar
- Hindorf, Cecilia
- Burnet, Jerome
- Quintanilla, Miguel
- Hingorani, Mohan
- Iggo, Richard
- Lemoine, NR
- Harrington, Kevin
- Vassaux, Georges
Publication date
November 2009
DOI Publisher
American Association for Cancer Research (AACR)Abstract
International audienceThe Na/I symporter (hNIS) promotes concentration of iodine in cells. In cancer gene therapy, this transgene has potential as a reporter gene for molecular imaging of viral biodistribution and as a therapeutic protein promoting (131)I-mediated radiotherapy. Here, we combined the imaging and therapeutic potential of hNIS in an oncolytic adenoviruses targeting colorectal cancer cells
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