International audienceThe liver has an exceptional replicative capacity following partial hepatectomy or chemical injuries. Cellular proliferation requires increased production of energy and essential metabolites, which critically depend on the mitochondria. To determine whether Top1mt, the vertebrate mitochondrial topoisomerase, is involved in this process, we studied liver regeneration after carbon tetrachloride (CCl4) administration. TOP1mt knockout (KO) mice showed a marked reduction in regeneration and hepatocyte proliferation. The hepatic mitochondrial DNA (mtDNA) failed to increase during recovery from CCl4 exposure. Reduced glutathione was also depleted, indicating increased reactive oxygen species (ROS). Steady-state levels of ATP,...
AbstractDNA topoisomerases pass DNA strands through each other, a function essential for all DNA met...
Abstract Background and aims: Hepatic ischemia-reperfusion injury (IRI) is the leading cause of ear...
Mitochondrial biogenesis and metabolism have recently emerged as important actors of stemness and di...
The liver has an exceptional replicative capacity following partial hepatectomy or chemical injuries...
Background: Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication a...
Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication and protein s...
Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to...
Topoisomerase I is essential for DNA metabolism in nuclei and mitochondria. In yeast, a single topoi...
Like any genome, mitochondrial DNA (mtDNA) also requires the action of topoisomerases to resolve top...
During CCl4 intoxication in rats, a disruption of hepatic mitochondrial structure and function occur...
Mitochondria contain their own genome (mtDNA), encoding 13 proteins of the enzyme complexes of the o...
Abstract Background and Aims: Hepatic ischemia–reperfusion injury (IRI) is the leading cause of earl...
The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at thousands of c...
International audienceMitochondrial DNA (mtDNA) is essential for cell viability because it encodes s...
Mitochondria are organelles that are essential for cellular homeostasis including energy harvesting ...
AbstractDNA topoisomerases pass DNA strands through each other, a function essential for all DNA met...
Abstract Background and aims: Hepatic ischemia-reperfusion injury (IRI) is the leading cause of ear...
Mitochondrial biogenesis and metabolism have recently emerged as important actors of stemness and di...
The liver has an exceptional replicative capacity following partial hepatectomy or chemical injuries...
Background: Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication a...
Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication and protein s...
Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to...
Topoisomerase I is essential for DNA metabolism in nuclei and mitochondria. In yeast, a single topoi...
Like any genome, mitochondrial DNA (mtDNA) also requires the action of topoisomerases to resolve top...
During CCl4 intoxication in rats, a disruption of hepatic mitochondrial structure and function occur...
Mitochondria contain their own genome (mtDNA), encoding 13 proteins of the enzyme complexes of the o...
Abstract Background and Aims: Hepatic ischemia–reperfusion injury (IRI) is the leading cause of earl...
The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at thousands of c...
International audienceMitochondrial DNA (mtDNA) is essential for cell viability because it encodes s...
Mitochondria are organelles that are essential for cellular homeostasis including energy harvesting ...
AbstractDNA topoisomerases pass DNA strands through each other, a function essential for all DNA met...
Abstract Background and aims: Hepatic ischemia-reperfusion injury (IRI) is the leading cause of ear...
Mitochondrial biogenesis and metabolism have recently emerged as important actors of stemness and di...