Supported pulmonary surfactant bilayers on silica nanoparticles: formulation, stability and impact on lung epithelial cells
- Mousseau, Fanny
- Puisney, Chloé
- Mornet, Stéphane
- Borgne, Rémi Le
- Vacher, Annie
- Airiau, Marc
- Baeza-Squiban, Armelle
- Berret, Jean-Francois
DOIAbstract
International audienceStudies have shown that following exposure to particulate matter, ultrafine fractions (<100 nm) may deposit along the respiratory tract down to the alveolar region. To assess the effects of nanoparticles on the lungs, it is essential to address the question of their biophysicochemical interaction with the different pulmonary environments, including the lung lining fluids and the epithelia. Here we examine one of these interactive scenarios and study the role of supported lipid bilayers (SLB) in the effect of 40 nm fluorescent silica particles on living cells. We first study the particle phase behavior in the presence of Curosurf®, a pulmonary surfactant substitute used in replacement therapies. It is found that Curosur...
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