The Impact of Age on Clinical Outcomes of Coronary Artery Bypass Grafting: Long-Term Results of a Real-World Registry.

Theaimof this retrospectivemulticenter registry study was to investigate age-dependent trends inmortality, long-termsurvival, and comorbidity over time in patientswho underwent isolated CABGfrom2003 to 2015.The percentage of patients < 60 years of agewas 18.9%. Female sex, chronic pulmonary disease, extracardiac arteriopathy, and neurologic dysfunction disease were significantly less frequent in this younger population. The prevalence of BMI ≥ 30, previous myocardial infarction, preoperative severe depressed left ventricular ejection fraction, and history of previous PCI were significantly higher in this population. After PS matching, at 5 years, patients < 60 years of age reported significantly lower overall mortality ( < 0.0001), cardiac-related mortality ( < 0.0001), incidence of acute myocardial infarction ( = 0.01), and stroke rates ( < 0.0001). Patients < 60 years required repeated revascularization more frequently than older patients ( = 0.05). Patients < 60 who underwent CABG had a lower risk of adverse outcomes than older patients. Patients < 60 have a different clinical pattern of presentation of CADin comparison with more elderly patients.These issues require focused attention in order to design and improve preventive strategies aiming to reduce the impact of specific cardiovascular risk factors for younger patients, such as diet, lifestyle, and weight control