The atrial natriuretic peptide genetic ariant rs5068 is associated with a favorable cardiometabolic phenotype in a mediterranean population

Cannone, Valentina
Cefalu, Angelo Baldassare
Noto, Davide
Scott, Christopher G.
Bailey, Kent R.
Cavera, Giovanni
Pagano, Michele
Sapienza, Michelangelo
Averna, Maurizio R.
Burnett Jr. , John C.

Open link

Publication date

January 2013

DOI

10.2337/dc12-2337

Publisher

American Diabetes Association

Abstract

OBJECTIVE-We hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population. RESEARCH DESIGN AND METHODS-We genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068. RESULTS-Genotype frequencies of rs5068 are AA, 93.5%; AG, 6.4%; and GG, 0.1%. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m2 [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is ...