Effects of Liraglutide on Weight Loss, Fat Distribution, and β-Cell Function in Obese Subjects With Prediabetes or Early Type 2 Diabetes
- Santilli, Francesca
- Simeone, Paola G
- Guagnano, Maria T
- Leo, Marika
- Maccarone, Marica T
- Di Castelnuovo, Augusto
- Sborgia, Cristina
- BONADONNA, Riccardo
- Angelucci, Ermanno
- Federico, Virginia
- Cianfarani, Stefano
- Manzoli, Lamberto
- Davì, Giovanni
- Tartaro, Armando
- Consoli, Agostino
DOIAbstract
Obesity is associated with an increased risk of type 2 diabetes and cardiovascular complications. The risk depends significantly on adipose tissue distribution. Liraglutide, a glucagon-like peptide 1 analog, is associated with weight loss, improved glycemic control, and reduced cardiovascular risk. We determined whether an equal degree of weight loss by liraglutide or lifestyle changes has a different impact on subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese subjects with prediabetes or early type 2 diabetes
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