Add to ORKGEngagement of cell surface adhesion receptors with extracellular constituents and with cellular counter-receptors is crucial for the extravasation of blood-borne neoplastic cells and their seeding at distant sites; however, the early events of tumor dissemination-ie, the intravasation step(s)-have been largely neglected. A role for the alpha4beta7 integrin was hypothesized to explain the high leukemogenicity exhibited by one (NQ22) among several T-cell lymphomas studied. To clarify the mechanisms of early aggressivity, the behavior of highly and poorly leukemogenic cell lines were compared in vitro. Cocultivation of physically separated leukemic cells with resting endothelial cells resulted in the up-regulation of VCAM-1 expression. NQ22 ce...
Several cell adhesion molecules that mediate the binding of lymphocytes to high endothelial venules ...
Metastasis to distant organs, a major cause of mortality from cancer, is often preceded by tumor spr...
characterized by widespread involve-ment of the bone marrow at the time of diagnosis, implying conti...
Engagement of cell surface adhesion receptors with extracellular constituents and with cellular coun...
Despite the presence of tumor-specific effector cells in the circulation of cancer patients, the imm...
Tumor‐associated lymphangiogenesis and lymphatic invasion of tumor cells correlate with poor outcome...
Local inflammation leads to increased expression of the vascular cell adhesion molecule (VCAM)-1 on ...
The interaction of blood-borne tumor cells with the vascular endothelium is a key component of hemat...
Despite the presence of tumor-specific effector cells in the circulation of cancer patients, the imm...
ICAM-1 and VCAM are cell adhesion receptors expressed on vascular endothelial cells, and their expre...
Tumour necrosis factor alpha (TNF-alpha) and interleukin 4 (IL-4) selectively synergise in inducing ...
Leukostasis and tissue infiltration by leukemic cells are poorly understood life-threatening complic...
Tumor-associated lymphangiogenesis and lymphatic invasion of tumor cells correlate with poor outcome...
An in vitro model using highly purified freshly isolated T cells demonstrated that immobilized ligan...
Recent data suggest that the generation of new lymphatic vessels (i.e. lymphangiogenesis) may be a r...
Several cell adhesion molecules that mediate the binding of lymphocytes to high endothelial venules ...
Metastasis to distant organs, a major cause of mortality from cancer, is often preceded by tumor spr...
characterized by widespread involve-ment of the bone marrow at the time of diagnosis, implying conti...
Engagement of cell surface adhesion receptors with extracellular constituents and with cellular coun...
Despite the presence of tumor-specific effector cells in the circulation of cancer patients, the imm...
Tumor‐associated lymphangiogenesis and lymphatic invasion of tumor cells correlate with poor outcome...
Local inflammation leads to increased expression of the vascular cell adhesion molecule (VCAM)-1 on ...
The interaction of blood-borne tumor cells with the vascular endothelium is a key component of hemat...
Despite the presence of tumor-specific effector cells in the circulation of cancer patients, the imm...
ICAM-1 and VCAM are cell adhesion receptors expressed on vascular endothelial cells, and their expre...
Tumour necrosis factor alpha (TNF-alpha) and interleukin 4 (IL-4) selectively synergise in inducing ...
Leukostasis and tissue infiltration by leukemic cells are poorly understood life-threatening complic...
Tumor-associated lymphangiogenesis and lymphatic invasion of tumor cells correlate with poor outcome...
An in vitro model using highly purified freshly isolated T cells demonstrated that immobilized ligan...
Recent data suggest that the generation of new lymphatic vessels (i.e. lymphangiogenesis) may be a r...
Several cell adhesion molecules that mediate the binding of lymphocytes to high endothelial venules ...
Metastasis to distant organs, a major cause of mortality from cancer, is often preceded by tumor spr...
characterized by widespread involve-ment of the bone marrow at the time of diagnosis, implying conti...