In our ongoing research program into the discovery of new anticancer drugs , we were interested in the preparation of naphthoquinone scaffolds bearing aminoalkyl side-chains. Following this aim, we revisited the KochiAnderson radical decarboxylation of amino acids in order to set up a versatile route to the direct functionalization of naphthoquinones. The best reaction conditions were applied to a selected series of compounds in a systematic methodological study which allowed us to establish important trends in reactivity. We found that a-substituted beta-amino acids were the most suitable substrates for the radical addition. In contrast, a-amino acids gave modest results. The influence of the amine protecting groups on the reaction outcome...
In chapter 1, general aspects of radical chemistry are briefly introduced. Improvements and applicat...
ABSTRACT: A combination of photoredox and palla-dium catalysis has been employed to facilitate the r...
International audienceVarious protected β2-amino acids can be prepared by radical addition of β-phth...
The reaction of 2-acetyl- and 2-benzoyl-1,4-naphthoquinone with (Z)-methyl 3-(hydroxymethyl)aminocro...
The synthesis of aminoquinones have been of extreme interest due to their wide spectrum of biologica...
5 pages, 1 figure, 3 schemes.-- Printed version published Sep 6, 2004.The radical decarboxylation of...
Many quinones are biologically active and beneficial for a variety of medicinal purposes including a...
An unusual and efficient method for the synthesis of new quinone-based amine and its derivatives fro...
Derivatives of 1,4-naphthoquinone play an important role in various biological processes through rea...
Amino Acid Decarboxylases are of great interest from both a mechanistic and therapeutic point of vie...
Biologically active quinones benefit various aspects of medicine including anticancer and antibacter...
This study demonstrates an unprecedented reactivity of 2-substituted-1,4-naphthoquinones. By applyin...
The key role of quinone substitution reactions in many biological processes, specifically anti-cance...
Absrracr: By exploiting the selective hydrogen atom transfer reactions of glycine residues in small ...
Chemistry of 9,10-anthraquinone and its derivatives have long stood out into an independent and larg...
In chapter 1, general aspects of radical chemistry are briefly introduced. Improvements and applicat...
ABSTRACT: A combination of photoredox and palla-dium catalysis has been employed to facilitate the r...
International audienceVarious protected β2-amino acids can be prepared by radical addition of β-phth...
The reaction of 2-acetyl- and 2-benzoyl-1,4-naphthoquinone with (Z)-methyl 3-(hydroxymethyl)aminocro...
The synthesis of aminoquinones have been of extreme interest due to their wide spectrum of biologica...
5 pages, 1 figure, 3 schemes.-- Printed version published Sep 6, 2004.The radical decarboxylation of...
Many quinones are biologically active and beneficial for a variety of medicinal purposes including a...
An unusual and efficient method for the synthesis of new quinone-based amine and its derivatives fro...
Derivatives of 1,4-naphthoquinone play an important role in various biological processes through rea...
Amino Acid Decarboxylases are of great interest from both a mechanistic and therapeutic point of vie...
Biologically active quinones benefit various aspects of medicine including anticancer and antibacter...
This study demonstrates an unprecedented reactivity of 2-substituted-1,4-naphthoquinones. By applyin...
The key role of quinone substitution reactions in many biological processes, specifically anti-cance...
Absrracr: By exploiting the selective hydrogen atom transfer reactions of glycine residues in small ...
Chemistry of 9,10-anthraquinone and its derivatives have long stood out into an independent and larg...
In chapter 1, general aspects of radical chemistry are briefly introduced. Improvements and applicat...
ABSTRACT: A combination of photoredox and palla-dium catalysis has been employed to facilitate the r...
International audienceVarious protected β2-amino acids can be prepared by radical addition of β-phth...