Carbonylation of C-N Bonds in Tertiary Amines Catalyzed by Low Valent Iron Catalysts

International audienceThe first iron catalysts able to promote the formal insertion of CO into the C-N bond of amines are reported. Using low valent iron complexes, including K2[Fe(CO)4], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl3 and Nd(OTf)3, have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars)