Asymmetric Synthesis of Enantiomerically Pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors

The enantioselective synthesis of (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG-4, 3), a potent and selective mGluR2 antagonist is described