Bone marrow (BM) angiogenesis is increased in Multiple Myeloma (MM) patients and correlates with disease progression and patient survival. Myeloma cells secrete the main endothelial growth factor VEGF. In mouse models VEGF secretion as well as the angiogenic properties of MM cells correlate with the lack of CD45 expression by MM cells. However, recent data indicate that VEGF plasma cell expression is similar between MGUS and MM patients suggesting that other molecules could be involved. In line with this hypothesis we have recently demonstrated that myeloma cells may also produce factors with angiogenic properties as angiopoietin-1 (ANG-1) and osteopontin (OPN) that are involved in myeloma induced angiogenesis in vitro. In order to identi...
Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, ce...
Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant expansion of malig...
Bone marrow (BM) angiogenesis has an important role in the initiation and progression of multiple my...
Several studies have shown a gradual increase in the extent of bone marrow angiogenesis in various s...
Tumor angiogenesis is a complex process involving interplay of several angiogenic regulators. In the...
The bone marrow microenvironment in multiple myeloma is characterized by an increased microvessel de...
Bone marrow neoangiogenesis plays an important role in multiple myeloma (MM) and depends on the inte...
Angiopoietin-2 (Ang-2) is involved in angiogenesis in both solid and hematological malignancies. In ...
Multiple myeloma (MM) progression closely depends on bone marrow (BM) angiogenesis. Several factors ...
International audienceAbundant bone marrow angiogenesis is present in almost all myeloma patients re...
Background: Multiple myeloma (MM) was the first hematological malignancy in which a prognostic relev...
Multiple myeloma (MM) is a plasma cell malignancy characterized by an increase of the bone marrow an...
Data on angiogenesis in the bone marrow of BCR-ABL1-negative myeloproliferative neoplasm (MPN) patie...
Multiple myeloma plasma cells home and expand in the bone marrow where cause an unbalanced bone remo...
Factor VIII-related antigen (FVIII-RA)-positive microvessel areas were measured by both immunohistoc...
Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, ce...
Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant expansion of malig...
Bone marrow (BM) angiogenesis has an important role in the initiation and progression of multiple my...
Several studies have shown a gradual increase in the extent of bone marrow angiogenesis in various s...
Tumor angiogenesis is a complex process involving interplay of several angiogenic regulators. In the...
The bone marrow microenvironment in multiple myeloma is characterized by an increased microvessel de...
Bone marrow neoangiogenesis plays an important role in multiple myeloma (MM) and depends on the inte...
Angiopoietin-2 (Ang-2) is involved in angiogenesis in both solid and hematological malignancies. In ...
Multiple myeloma (MM) progression closely depends on bone marrow (BM) angiogenesis. Several factors ...
International audienceAbundant bone marrow angiogenesis is present in almost all myeloma patients re...
Background: Multiple myeloma (MM) was the first hematological malignancy in which a prognostic relev...
Multiple myeloma (MM) is a plasma cell malignancy characterized by an increase of the bone marrow an...
Data on angiogenesis in the bone marrow of BCR-ABL1-negative myeloproliferative neoplasm (MPN) patie...
Multiple myeloma plasma cells home and expand in the bone marrow where cause an unbalanced bone remo...
Factor VIII-related antigen (FVIII-RA)-positive microvessel areas were measured by both immunohistoc...
Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, ce...
Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant expansion of malig...
Bone marrow (BM) angiogenesis has an important role in the initiation and progression of multiple my...