Polymorphism of TNF-alfa but not MDR-1 influence response to medical therapy in pediatric onset inflammatory bowel disease. (I.F. 2.102)

Aim: We investigated the contribution of variants of tumour necrosis factor (TNF)-a and MDR1 genes in the predisposition and response to medical therapy in a large pediatric cohort of patients with Crohn disease (CD) and ulcerative colitis (UC). Patients and Methods: In this study, 200 patients with CD, 186 patients with UC, 434 parents (217 trios), and 347 healthy unrelated controls were investigated. Single-nucleotide polymorphisms G308A and C857T of the TNF-a gene and C3435T of the MDR1 gene were investigated and correlated with clinical subphenotypes and efficacy of medical therapy. Results: The frequency of the 308A allele of the TNF-a gene was significantly increased in both patients with CD (15%; odds ratio [OR]¼2.79; P<0.01) and patients with UC (11%; OR¼1.96; P<0.003) compared with controls (6%). Carriers of this allele were 27% in CD (OR¼2.94; P