The expression of the osmosensitive sodium/myo-inositol cotransporter (SMIT) is regulated by multiple tonicity-responsive enhancers (TonEs) in the 5'-flanking region of the gene. In response to hypertonicity, the nuclear abundance of the transcription factor TonE-binding protein (TonEBP) is increased, and the transcription of the SMIT gene is induced. Transport system A for neutral amino acids, another osmosensitive mechanism, is progressively stimulated if amino acid substrates are not present in the extracellular compartment. Under this condition, as in hypertonicity, cells shrink and mitogen-activated protein kinases are activated. We demonstrate here that a clear-cut nuclear redistribution of TonEBP, followed by SMIT expression increase...
In cultured human fibroblasts incubated under hypertonic conditions, the stimulation of system A for...
Most organisms respond to a hypertonic environment by accumulating small organic solutes. In contras...
Regulatory volume increase (RVI) has been studied in cultured human fibroblasts (CHF) incubated in a...
The expression of the osmosensitive sodium/myo-inositol cotransporter (SMIT) is regulated by multipl...
Hypertonicity (most often present as high salinity) is stressful to the cells of virtually all organ...
he sodium/myo-inositol cotransporter is a plasma membrane protein responsible for concentrative cell...
Tonicity-responsive enhancer binding protein (TonEBP) regulates transcription of tonicity responsive...
Tyrosine kinase inhibitors and immunosuppressants perturb the myo-inositol but not the betaine cotra...
The accumulation of compatible osmolytes during osmotic stress is observed in virtually all organism...
Cells of the hypertonic renal medulla accumulate high concentrations of the non-perturbing osmolytes...
AbstractIn cultured human fibroblasts incubated under hypertonic conditions, the stimulation of syst...
Myo-inositol is a major compatible osmolyte accumulated in the hypertonic renal medulla and in Madin...
Background. The sodium/myo-inositol cotransporter (SMIT) and the betaine cotransporter (BGT1) are es...
Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization.BackgroundI...
Sodium-dependent neutral amino acid transporter-2 (SNAT2), the ubiquitous member of SLC38 family, a...
In cultured human fibroblasts incubated under hypertonic conditions, the stimulation of system A for...
Most organisms respond to a hypertonic environment by accumulating small organic solutes. In contras...
Regulatory volume increase (RVI) has been studied in cultured human fibroblasts (CHF) incubated in a...
The expression of the osmosensitive sodium/myo-inositol cotransporter (SMIT) is regulated by multipl...
Hypertonicity (most often present as high salinity) is stressful to the cells of virtually all organ...
he sodium/myo-inositol cotransporter is a plasma membrane protein responsible for concentrative cell...
Tonicity-responsive enhancer binding protein (TonEBP) regulates transcription of tonicity responsive...
Tyrosine kinase inhibitors and immunosuppressants perturb the myo-inositol but not the betaine cotra...
The accumulation of compatible osmolytes during osmotic stress is observed in virtually all organism...
Cells of the hypertonic renal medulla accumulate high concentrations of the non-perturbing osmolytes...
AbstractIn cultured human fibroblasts incubated under hypertonic conditions, the stimulation of syst...
Myo-inositol is a major compatible osmolyte accumulated in the hypertonic renal medulla and in Madin...
Background. The sodium/myo-inositol cotransporter (SMIT) and the betaine cotransporter (BGT1) are es...
Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization.BackgroundI...
Sodium-dependent neutral amino acid transporter-2 (SNAT2), the ubiquitous member of SLC38 family, a...
In cultured human fibroblasts incubated under hypertonic conditions, the stimulation of system A for...
Most organisms respond to a hypertonic environment by accumulating small organic solutes. In contras...
Regulatory volume increase (RVI) has been studied in cultured human fibroblasts (CHF) incubated in a...