The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor Gene in Coping Strategies Relevant to Depressive Symptoms
- Caldwell, W. (Warren)
- McInnis, O.A. (Opal A.)
- McQuaid, R.J. (Robyn J.)
- Liu, G. (Gele)
- Stead, J. (John)
- Anisman, H. (Hymie)
- Hayley, S. (Shawn)
DOIAbstract
Disturbances of brain derived neurotrophic factor (BDNF) signalling have been implicated in the evolution of depression, which likely arises, in part, as a result of diminished synaptic plasticity. Predictably, given stressor involvement in depression, BDNF is affected by recent stressors as well as stressors such as neglect experienced in early life. The effects of early li
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