Gene expression profiling of lung atypical carcinoids and large cell neuroendocrine carcinomas identifies three transcriptomic subtypes with specific genomic alterations
- Simbolo, Michele
- Barbi, Stefano
- Fassan, Matteo
- Mafficini, Andrea
- Ali, Greta
- Vicentini, Caterina
- Sperandio, Nicola
- Corbo, Vincenzo
- Rusev, Borislav
- Mastracci, Luca
- Grillo, Federica
- Pilotto, Sara
- Pelosi, Giuseppe
- Pelliccioni, Serena
- Lawlor, Rita T
- Tortora, Giampaolo
- Fontanini, Gabriella
- Volante, Marco
- Scarpa, Aldo
- Bria, Emilio
DOIAbstract
DNA mutational profiling showed that atypical carcinoids (ACs) share alterations with large-cell neuroendocrine carcinomas (LCNECs). Transcriptomic studies suggested that LCNEC are composed of two subtypes, one of which shares molecular anomalies with small-cell lung cancer. The missing piece of information is the transcriptomic relationship between AC and LCNEC, as a direct comparison is lacking in literature
Add to ORKG