Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation
- Angiolilli, Chiara
- Kabala, Pawel A
- Grabiec, Aleksander M
- Rossato, Marzia
- Lai, Wi S
- Fossati, Gianluca
- Mascagni, Paolo
- Steinkühler, Christian
- Blackshear, Perry J
- Reedquist, Kris A
- Baeten, Dominique L
- Radstake, Timothy R D J
Publication date
January 2018
DOI Publisher
Springer Science and Business Media LLCAbstract
Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) on the transcriptional and post-transcriptional regulation of inflammatory markers in RA fibroblast-like synoviocytes (FLS)
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