It has been well demonstrated that TNF-alpha is integral to the pathogenesis of multiple organ dysfunction syndrome (MODS). In this study, we investigate the effects of etanercept (10 mg/kg, s.c.), a specific TNF-alpha-soluble inhibitor, on the acute phase and late mortality in a murine model of MODS of nonseptic origin induced by zymosan (500 mg/kg, suspended in saline solution, i.p.). Etanercept was administered 1 h after the injection of zymosan. Animals were killed after 18 h. In another set of experiments, mice were monitored for systemic toxicity, loss of body weight, and mortality for 12 days. Sham-treated and TNF receptor 1 (TNFR1)-deficient animals were used as control. Treatment of mice with Etanercept and TNFR1 gene deletion decr...
TNF-alpha has proved to be a successful target in the treatment of many peripheral inflammatory dise...
Patients suffering from multiple organ dysfunction syndrome (MODS) comprise a heterogeneous populati...
INTRODUCTION: Tumor necrosis factor (TNF)-alpha mediates inflammation and apoptosis in ischemia-repe...
TNF-alpha plays a pivotal role in the pathogenesis of acute pancreatitis. Recent studies have shown ...
Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that results...
Experimental evidence suggests that interleukin (IL)-10 plays a pivotal role in generalized inflamma...
OBJECTIVE: Multiple-organ failure (MOF) is defined as the progressive deterioration in function w...
Item does not contain fulltextOBJECTIVE: To examine the role of inducible nitric oxide synthase (iNO...
<p>Etanercept was administered 30 min before AOM. Plasma TNF-α (A), IL-6 (B) and CD40L (C) were quan...
Etanercept is a tumor necrosis factor antagonist with anti-inflammatory effects. The aim of our stud...
Background/aims: Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condi...
The role of tumour necrosis factor (TNF)-alpha or cyclo-oxygenase-2 (COX-2) eicosanoids in dystrophi...
The role of tumour necrosis factor (TNF)-α or cyclo-oxygenase-2 (COX-2) eicosanoids in dystrophinopa...
The definitive version is available at www.blackwell-synergy.comHigh levels of tumor necrosis factor...
We aimed to investigate the effect of etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, on ra...
TNF-alpha has proved to be a successful target in the treatment of many peripheral inflammatory dise...
Patients suffering from multiple organ dysfunction syndrome (MODS) comprise a heterogeneous populati...
INTRODUCTION: Tumor necrosis factor (TNF)-alpha mediates inflammation and apoptosis in ischemia-repe...
TNF-alpha plays a pivotal role in the pathogenesis of acute pancreatitis. Recent studies have shown ...
Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that results...
Experimental evidence suggests that interleukin (IL)-10 plays a pivotal role in generalized inflamma...
OBJECTIVE: Multiple-organ failure (MOF) is defined as the progressive deterioration in function w...
Item does not contain fulltextOBJECTIVE: To examine the role of inducible nitric oxide synthase (iNO...
<p>Etanercept was administered 30 min before AOM. Plasma TNF-α (A), IL-6 (B) and CD40L (C) were quan...
Etanercept is a tumor necrosis factor antagonist with anti-inflammatory effects. The aim of our stud...
Background/aims: Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condi...
The role of tumour necrosis factor (TNF)-alpha or cyclo-oxygenase-2 (COX-2) eicosanoids in dystrophi...
The role of tumour necrosis factor (TNF)-α or cyclo-oxygenase-2 (COX-2) eicosanoids in dystrophinopa...
The definitive version is available at www.blackwell-synergy.comHigh levels of tumor necrosis factor...
We aimed to investigate the effect of etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, on ra...
TNF-alpha has proved to be a successful target in the treatment of many peripheral inflammatory dise...
Patients suffering from multiple organ dysfunction syndrome (MODS) comprise a heterogeneous populati...
INTRODUCTION: Tumor necrosis factor (TNF)-alpha mediates inflammation and apoptosis in ischemia-repe...