Myeloid leukocyte recruitment into the lung in response to environmental cues represents a key factor for the induction of lung damage. We report that Hck- and Fgr-deficient mice show a profound impairment in early recruitment of neutrophils and monocytes in response to bacterial LPS. The reduction in interstitial and airway neutrophil recruitment was not due to a cell-intrinsic migratory defect, because Hck- and Fgr-deficient neutrophils were attracted to the airways by the chemokine CXCL2 as wild type cells. However, early accumulation of chemokines and TNF-α in the airways was reduced in hck(-/-)fgr(-/-) mice. Considering that chemokine and TNF-α release into the airways was neutrophil independent, as suggested by a comparison between co...
Pulmonary bacterial infections are a leading cause of death. Since the introduction of antibiotics, ...
© 2014 Kova´cs et al.Although Src family kinases participate in leukocyte function in vitro, such as...
Early inflammatory events include cytokine release, activation, and rapid accumulation of neutrophil...
C1 - Journal Articles RefereedTo identify the physiological role of Hck, a functionally redundant me...
The chemotactic peptide formyl-methionyl-leucyl-phenilalanine (fMLP) triggers intracellular protein ...
SummaryIn classical descriptions of leukocyte chemokine signaling, Src family kinases are thought to...
Although Src family kinases participate in leukocyte function in vitro, such as integrin signal tran...
Abstract: Myeloid cells, including neutrophils and macrophages, play important roles in innate immun...
Cross-linking of the neutrophil-beta 2- or beta 3-related leukocyte response integrins by extracellu...
Background: Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP-1) controls the intracel...
Introduction. Chemokines are capable of recruiting specific leukocytes. The CXC chemokines KC and MI...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality in the United S...
AbstractTo establish whether the widely expressed regulator of Src family kinases Csk contributes to...
BACKGROUND: Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myelo...
Autoinflammatory diseases include a number of monogenic systemic inflammatory diseases, as well as a...
Pulmonary bacterial infections are a leading cause of death. Since the introduction of antibiotics, ...
© 2014 Kova´cs et al.Although Src family kinases participate in leukocyte function in vitro, such as...
Early inflammatory events include cytokine release, activation, and rapid accumulation of neutrophil...
C1 - Journal Articles RefereedTo identify the physiological role of Hck, a functionally redundant me...
The chemotactic peptide formyl-methionyl-leucyl-phenilalanine (fMLP) triggers intracellular protein ...
SummaryIn classical descriptions of leukocyte chemokine signaling, Src family kinases are thought to...
Although Src family kinases participate in leukocyte function in vitro, such as integrin signal tran...
Abstract: Myeloid cells, including neutrophils and macrophages, play important roles in innate immun...
Cross-linking of the neutrophil-beta 2- or beta 3-related leukocyte response integrins by extracellu...
Background: Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP-1) controls the intracel...
Introduction. Chemokines are capable of recruiting specific leukocytes. The CXC chemokines KC and MI...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality in the United S...
AbstractTo establish whether the widely expressed regulator of Src family kinases Csk contributes to...
BACKGROUND: Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myelo...
Autoinflammatory diseases include a number of monogenic systemic inflammatory diseases, as well as a...
Pulmonary bacterial infections are a leading cause of death. Since the introduction of antibiotics, ...
© 2014 Kova´cs et al.Although Src family kinases participate in leukocyte function in vitro, such as...
Early inflammatory events include cytokine release, activation, and rapid accumulation of neutrophil...