VEGF-A clinical significance in gastric cancers: Immunohistochemical analysis of a wide Italian cohort
- Lastraioli E
- Boni L
- Romoli MR
- Crescioli S
- Taddei A
- Vindigni C
- Saragoni L
- Messerini L
- Bernini M
- Bencini L
- Giommoni E
- Freschi G
- Di Costanzo F
- Morgagni P
- Farsi M
- Roviello F
- Bechi P
- Arcangeli A
- Gruppo Italiano di Ricerca Cancro Gastrico
- BEGHELLI, Stefania
- Tomezzoli, Anna
- SCARPA, Aldo
- DE MANZONI, Giovanni
DOIAbstract
PURPOSE: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens. METHODS: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters. RESULTS: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis. CONCLUSIONS: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk
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