Divergences in Insulin Resistance Between the Different Phenotypes of the Polycystic Ovary Syndrome.

Context/Objective: Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different diagnostic feature combinations found in each patient. Our aim was to assess whether either each single diagnostic feature or their combinations into the PCOS phenotypes may predict insulin resistance in these women.Patients/Design: One hundred thirty-seven consecutive Caucasian women with PCOS, diagnosed by the Rotterdam criteria, underwent accurate assessment of diagnostic and metabolic features. Insulin sensitivity was measured by the glucose clamp technique.Results: Among PCOS women, 84.7% had hyperandrogenism, 84.7% chronic oligoanovulation, and 89% polycystic ovaries. According to the individual combinations of these features‬, 69.4% of women had the Classic, 15.3% the Ovulatory and 15.3% the Normoandrogenic phenotype. Most subjects (71.4%) were insulin resistant. However, insulin resistance frequency differed between phenotypes, being 80.4, 65.0 and 38.1% respectively in the three subgroups (p