During behavioral quiescence, the neocortex generates spontaneous slow oscillations, which may consist of up-states and down-states. Up-states are short epochs of persistent activity that resemble the activated neocortex during arousal and cognition. Neural activity in neocortical pathways can trigger up-states, but the variables that control their occurrence are poorly understood. We used thalamocortical slices from adult mice to explore the role of thalamocortical and intracortical synaptic cooperativity (the number of coincident afferents) in driving up-states. Cooperativity was adjusted by varying the intensity of electrical or blue-light stimuli in pathways that express channelrhodopsin-2. We found that optogenetics greatly improves th...
Slow-wave sleep is thought to be important for retuning cortical synapses, but the cellular mechanis...
The functions of sleep are diverse and still poorly understood, but a strong effect on cognition is...
Neuronal ensembles are coactive groups of cortical neurons, found in spontaneous and evoked activity...
During behavioral quiescence the neocortex generates spontaneous slow oscillations that consist of U...
Although neocortex underlies higher-order brain functions, little is known about the synaptic intera...
The thalamus provides fundamental input to the neocortex. This input activates inhibitory interneuro...
SummaryBackgroundSynaptic interactions between excitatory and inhibitory neocortical neurons are imp...
Slow-wave sleep is characterized by near-synchronous alternation of active Up states and quiescent D...
The neocortex is organized into local recurrent microcircuits that are connected along vertical colu...
Cortical neurons in vitro and in vivo fluctuate spontaneously between two stable membrane potentials...
Parvalbumin-containing fast-spiking interneurons (FSIs) exert a powerful feed-forward GABAergic inhi...
BACKGROUND: The cerebral cortex is permanently active during both awake and sleep states. This ongoi...
Slow wave sleep is characterised by synchronised slow oscillations, which manifest themselves in cor...
Thalamus and cortex represent a highly integrated processing unit that elaborates sensory representa...
Sensory experience and perceptual learning changes receptive field properties of cortical pyramidal ...
Slow-wave sleep is thought to be important for retuning cortical synapses, but the cellular mechanis...
The functions of sleep are diverse and still poorly understood, but a strong effect on cognition is...
Neuronal ensembles are coactive groups of cortical neurons, found in spontaneous and evoked activity...
During behavioral quiescence the neocortex generates spontaneous slow oscillations that consist of U...
Although neocortex underlies higher-order brain functions, little is known about the synaptic intera...
The thalamus provides fundamental input to the neocortex. This input activates inhibitory interneuro...
SummaryBackgroundSynaptic interactions between excitatory and inhibitory neocortical neurons are imp...
Slow-wave sleep is characterized by near-synchronous alternation of active Up states and quiescent D...
The neocortex is organized into local recurrent microcircuits that are connected along vertical colu...
Cortical neurons in vitro and in vivo fluctuate spontaneously between two stable membrane potentials...
Parvalbumin-containing fast-spiking interneurons (FSIs) exert a powerful feed-forward GABAergic inhi...
BACKGROUND: The cerebral cortex is permanently active during both awake and sleep states. This ongoi...
Slow wave sleep is characterised by synchronised slow oscillations, which manifest themselves in cor...
Thalamus and cortex represent a highly integrated processing unit that elaborates sensory representa...
Sensory experience and perceptual learning changes receptive field properties of cortical pyramidal ...
Slow-wave sleep is thought to be important for retuning cortical synapses, but the cellular mechanis...
The functions of sleep are diverse and still poorly understood, but a strong effect on cognition is...
Neuronal ensembles are coactive groups of cortical neurons, found in spontaneous and evoked activity...