The use of intravenous nitrogen-containing bisphosphonates (N-BPs) is associated with the appearance of an acute phase response (APR) in a proportion of the patients for reasons which are poorly understood. The APR was attributed to the indirect activation of γδ T cells with the release of interferon-γ and TNF. Forty patients with postmenopausal or senile osteoporosis (age range 53-91 years) never previously treated with intravenous (i.v.) bisphosphonate, received a single 5 mg zoledronic acid (ZOL) i.v. infusion over 15 min. White blood cells were counted and analysed with an automated haematology analyzer (ADVIA 2120i Siemens) and by flow cytometer (BD FACSCanto, Becton Dickinson). The occurrence of APR was defined by the occurrence of fe...
The bisphosphonates are a novel class of drug that have been registered for various clinical applica...
To investigate the prevalence of fever after intravenous injection of for the first time in osteopor...
Introduciton Amino-bisphosphonates are potent activators of human gamma delta T cells. The aim of ou...
We have recently reported a long-lasting decrease in circulating γδ T cells in osteoporotic patients...
The aim of this study was to explore whether desensitization to the occurrence of the acute-phase re...
Aminobisphosphonates (NBPs) are used widely against excessive bone resorption in osteoporosis and Pa...
Aminobisphosphonates (NBPs) are used widely against excessive bone resorption in osteoporosis and P...
Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute p...
Acute phase response (APR) following intravenous zoledronate (ZOL) administration is related to acti...
Infusions of aminobisphosphonates are now established therapies ofpostmenopausal osteoporosis. Their...
In patients who have never previously received bisphosphonate therapy, the intravenous administratio...
Aminobisphosphonates (NBP) are used for treatment of metastatic bone disease. Frequently, patients u...
A first intravenous dose of bisphosphonates may be associated with an acute-phase response (APR). In...
ABSTRACT: Background: Several studies have investigated the immunomodulating properties of zoledron...
The most common adverse event typically associated with bisphosphonate therapy is transient fever. T...
The bisphosphonates are a novel class of drug that have been registered for various clinical applica...
To investigate the prevalence of fever after intravenous injection of for the first time in osteopor...
Introduciton Amino-bisphosphonates are potent activators of human gamma delta T cells. The aim of ou...
We have recently reported a long-lasting decrease in circulating γδ T cells in osteoporotic patients...
The aim of this study was to explore whether desensitization to the occurrence of the acute-phase re...
Aminobisphosphonates (NBPs) are used widely against excessive bone resorption in osteoporosis and Pa...
Aminobisphosphonates (NBPs) are used widely against excessive bone resorption in osteoporosis and P...
Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute p...
Acute phase response (APR) following intravenous zoledronate (ZOL) administration is related to acti...
Infusions of aminobisphosphonates are now established therapies ofpostmenopausal osteoporosis. Their...
In patients who have never previously received bisphosphonate therapy, the intravenous administratio...
Aminobisphosphonates (NBP) are used for treatment of metastatic bone disease. Frequently, patients u...
A first intravenous dose of bisphosphonates may be associated with an acute-phase response (APR). In...
ABSTRACT: Background: Several studies have investigated the immunomodulating properties of zoledron...
The most common adverse event typically associated with bisphosphonate therapy is transient fever. T...
The bisphosphonates are a novel class of drug that have been registered for various clinical applica...
To investigate the prevalence of fever after intravenous injection of for the first time in osteopor...
Introduciton Amino-bisphosphonates are potent activators of human gamma delta T cells. The aim of ou...