Add to ORKGOBJECTIVES: The purpose of the present study was to investigate the effect of novel genetic factors on plasma levels of total homocysteine (tHcy) and fibrinogen (FIB). As tHcy and FIB have been consistently associated to increased risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) also genes-trait-MI mediational effects were tested. METHODS: A complex segregation analysis, and a mediation analysis of a highly selected group of 44 extended families (302 subjects), each including at least one member with fatal premature (<50 years) IHD were carried out. RESULTS: tHcy and FIB levels turned out to be influenced by at least two major genes. A significant tHcy latent class-MI association (OR = 3.24; 95% CI, 1.37 to 7....
Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in pl...
Background Moderately elevated blood levels of homocysteine are weakly correlated with coronary hear...
Contains fulltext : 50783.pdf (publisher's version ) (Closed access)Elevated total...
BACKGROUND: The strong observational association between total homocysteine (tHcy) concentrations an...
Background: The strong observational association between total homocysteine (tHcy) concentrations an...
Total plasma homocysteine concentration (tHcy) is a biomarker for atherothrombotic disease, but caus...
BACKGROUND: The interaction between genetic and environmental risk factors in determining premature ...
Elevated levels of homocysteine is a risk factor for coronary artery disease. Polymorphic alleles in...
Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disea...
Family history of coronary heart disease (CHD) has frequently been shown to increase the risk of MI....
Background: Elevated homocysteine is associated with ischaemic heart disease (IHD). The C677T polymo...
Contains fulltext : 80617.pdf (publisher's version ) (Open Access)Homocysteine is ...
Purpose: The role of homocysteine in the pathogenesis of arteriosclerosis and stroke is under debate...
Background and Purpose-Homocysteine levels are determined by genetic and environmental factors. Seve...
Several epidemiological studies have found that the plasma fibrinogen level is a risk factor for isc...
Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in pl...
Background Moderately elevated blood levels of homocysteine are weakly correlated with coronary hear...
Contains fulltext : 50783.pdf (publisher's version ) (Closed access)Elevated total...
BACKGROUND: The strong observational association between total homocysteine (tHcy) concentrations an...
Background: The strong observational association between total homocysteine (tHcy) concentrations an...
Total plasma homocysteine concentration (tHcy) is a biomarker for atherothrombotic disease, but caus...
BACKGROUND: The interaction between genetic and environmental risk factors in determining premature ...
Elevated levels of homocysteine is a risk factor for coronary artery disease. Polymorphic alleles in...
Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disea...
Family history of coronary heart disease (CHD) has frequently been shown to increase the risk of MI....
Background: Elevated homocysteine is associated with ischaemic heart disease (IHD). The C677T polymo...
Contains fulltext : 80617.pdf (publisher's version ) (Open Access)Homocysteine is ...
Purpose: The role of homocysteine in the pathogenesis of arteriosclerosis and stroke is under debate...
Background and Purpose-Homocysteine levels are determined by genetic and environmental factors. Seve...
Several epidemiological studies have found that the plasma fibrinogen level is a risk factor for isc...
Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in pl...
Background Moderately elevated blood levels of homocysteine are weakly correlated with coronary hear...
Contains fulltext : 50783.pdf (publisher's version ) (Closed access)Elevated total...