Chemokines are a small group of related chemo-attractant peptides that play an essential role in the homeostatic maintenance of the immune system. They control the recruitment of cells needed for the induction and activation of innate and adaptive immune responses. However, tumors also utilize chemokines to actively progress and evade immunosurveillance. In fact, chemokines are involved directly or indirectly in almost every aspect of tumorigenesis. They mediate survival and metastatic spread of tumors, promote new blood vessel formation (neovascularization) and induce an immunosuppressive microenvironment via recruitment of immunosuppressive cells. As a result, a number of therapeutic strategies have been proposed to target almost every st...
Recent studies have highlighted the possible involvement of chemokines and their receptors in breast...
Abstract: It is clear from large clinical studies that selected chemokine receptors are often up-reg...
We are witnessing a new era of immune-mediated cancer therapies and vaccine development. As the fiel...
Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes ...
Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have demonstrated st...
Innate and adaptive immune cells can intervene during tumor progression at different stages includin...
Chemokines are a large family of small chemotactic cytokines that coordinates immune cell traffickin...
Both innate and adaptive immune responses have an essential role in protection against tumor cells. ...
Chemokines were initially identified as bioactive substances, which control the trafficking of infla...
Metastasis still represents the primary cause of cancer morbidity and mortality worldwide. Chemokine...
A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding...
Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors ar...
Metastases are the cause of 90% of human cancer deaths. The current treatment of cancer with chemo,-...
Chemokines are small secreted proteins that orchestrate migration and positioning of immune cells wi...
Chemokines interact with glycosaminoglycans of the extracellular matrix and activate heptahelical ce...
Recent studies have highlighted the possible involvement of chemokines and their receptors in breast...
Abstract: It is clear from large clinical studies that selected chemokine receptors are often up-reg...
We are witnessing a new era of immune-mediated cancer therapies and vaccine development. As the fiel...
Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes ...
Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have demonstrated st...
Innate and adaptive immune cells can intervene during tumor progression at different stages includin...
Chemokines are a large family of small chemotactic cytokines that coordinates immune cell traffickin...
Both innate and adaptive immune responses have an essential role in protection against tumor cells. ...
Chemokines were initially identified as bioactive substances, which control the trafficking of infla...
Metastasis still represents the primary cause of cancer morbidity and mortality worldwide. Chemokine...
A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding...
Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors ar...
Metastases are the cause of 90% of human cancer deaths. The current treatment of cancer with chemo,-...
Chemokines are small secreted proteins that orchestrate migration and positioning of immune cells wi...
Chemokines interact with glycosaminoglycans of the extracellular matrix and activate heptahelical ce...
Recent studies have highlighted the possible involvement of chemokines and their receptors in breast...
Abstract: It is clear from large clinical studies that selected chemokine receptors are often up-reg...
We are witnessing a new era of immune-mediated cancer therapies and vaccine development. As the fiel...