Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medullary thyroid carcinoma (MTC) associated (MEN 2A and 2B) or not familial MTC (FMTC) with other endocrine neoplasia due to germline RET gene mutations. The prevalence of these rare genetic diseases and their corresponding RET mutations are unknown due to the small size of the study population. METHODS: We collected data on germline RET mutations of 250 families with hereditary MTC followed in 20 different Italian centres. RESULTS AND CONCLUSIONS: The most frequent RET amino acid substitution was Val804Met (19.6%) followed by Cys634Arg (13.6%). A total of 40 different germline RET mutations were present. Six families (2.4%) were negative for germline R...
BACKGROUND: Germline RET gene mutations are causative of multiple endocrine neoplasia (MEN) 2 and m...
<p>Background: Germline missense mutations of the RET protooncogene cause a clinical spectrum called...
BACKGROUD: Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal domi...
OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medu...
OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medul...
OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medulla...
Objective: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medulla...
Objective: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medulla...
Multiple endocrine neoplasia type 2 (MEN 2 syndrome) is a rare syndrome, inherited in an autosomal d...
Multiple endocrine neoplasia (MEN) are clinical inherited syndromes affecting different endocrine gl...
Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant cancer predisposition syndrome,...
Background: We previously identified a four-generation family with medullary thyroid cancer (MTC) an...
Background : Germline RET gene mutations are well known to be the genetic causes of multiple endocri...
OBJECTIVE: Genetic screening of RET proto-oncogene is a powerful tool for the early identification...
The multiple endocrine neoplasia (MEN) syndromes are hereditary monogenic diseases that are transmit...
BACKGROUND: Germline RET gene mutations are causative of multiple endocrine neoplasia (MEN) 2 and m...
<p>Background: Germline missense mutations of the RET protooncogene cause a clinical spectrum called...
BACKGROUD: Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal domi...
OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medu...
OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medul...
OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medulla...
Objective: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medulla...
Objective: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medulla...
Multiple endocrine neoplasia type 2 (MEN 2 syndrome) is a rare syndrome, inherited in an autosomal d...
Multiple endocrine neoplasia (MEN) are clinical inherited syndromes affecting different endocrine gl...
Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant cancer predisposition syndrome,...
Background: We previously identified a four-generation family with medullary thyroid cancer (MTC) an...
Background : Germline RET gene mutations are well known to be the genetic causes of multiple endocri...
OBJECTIVE: Genetic screening of RET proto-oncogene is a powerful tool for the early identification...
The multiple endocrine neoplasia (MEN) syndromes are hereditary monogenic diseases that are transmit...
BACKGROUND: Germline RET gene mutations are causative of multiple endocrine neoplasia (MEN) 2 and m...
<p>Background: Germline missense mutations of the RET protooncogene cause a clinical spectrum called...
BACKGROUD: Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal domi...