Pro-atherogenic postprandial profile: Meal-induced changes of lipoprotein sub-fractions and inflammation markers in obese boys.

BACKGROUND AND AIMS: Obesity is a pro-atherogenic condition and postprandial lipoprotein profile and circulating cytokines changes may contribute to promote the process. The aim of this study is to investigate postprandial metabolic response, lipoprotein oxidation and circulating cytokine levels, after the ingestion of two different meals with different fat/carbohydrate ratio. METHODS AND RESULTS: Ten prepubertal obese boys consumed two meals with the same energy and protein content but with a different carbohydrate to fat ratio: 1) moderate fat (MF): 61\% carbohydrate, 27\% fat; 2) high fat (HF): 37\% carbohydrate, 52\% fat. The AUC of glucose and insulin were significantly (p 0.3, P < 0.05) was observed between the densest LDL particles and the ox-LDL plasma levels. A reduction of IL-6 was found at 120 min after the MF [-23.3(5.5) vs -8.4(3.8)\% from baseline, P < 0.05)] compared with the HF meal. CONCLUSION: A simple change of ≈25\% of energy load from fat to carbohydrate in a meal significantly improves postprandial pro-atherogenic factors in obese boys