Very low levels of vitamin D in systemic sclerosis patients
- Caramaschi, Paola
- RUZZENENTE, Orazio
- VOLPE, Alessandro
- RAVAGNANI, Viviana
- TINAZZI, Ilaria
- BARAUSSE, Giovanni
- BAMBARA, Lisa Maria
- BIASI, Domenico
- DALLA GASSA, ALESSANDRA
DOIAbstract
Vitamin D displays many extraosseous immunomodulatory effects. The aim of the study was to evaluate the level of vitamin D in patients with systemic sclerosis (SSc) and to analyze the associations between the concentration of the vitamin and clinical manifestations. In March-April 2009, 65 consecutive SSc patients underwent evaluation of vitamin D concentrations by the LIAISON immunoassay (normal 30-100 ng/ml). Serum levels between 10 and 30 ng/ml were classified as vitamin D insufficiency, while concentrations <10 ng/ml as vitamin D deficiency. None of the patients were receiving vitamin D supplementation at the time of or during the year prior to study entry. The mean level of vitamin D was 15.8 +/- 9.1 ng/ml. Only three cases showed norm...
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