Common variants conferring risk of schizophrenia
- Stefansson H.
- Ophoff R. A.
- Steinberg S.
- Andreassen O. A.
- Chichon S.
- Rujescu D.
- Werge T.
- Pietilainen O. P.
- Mors O.
- Mortensen P. B.
- Sigurdsson E.
- Gustafsson O.
- Nyegaard M.
- Tuulio Henriksson A.
- Ingason A.
- Hansen T.
- Suvisaari J.
- Lonnqvist J.
- Paunio T.
- Borglum A. D.
- Hartmann A.
- Fink Jensen A.
- Nordentoft M.
- Hougaard D.
- Norgaard Petersen B.
- Bottcher J.
- Olesen J.
- Breuer R.
- Moller H. J.
- Giegling I.
- Rasmussen H. B.
- Timm S.
- Mattheisen M.
- Bitter I.
- Rethelyi J. M.
- Magnusdottir B. B.
- Sigmundsson T.
- Olason P. I.
- Masson G.
- Gulcher J. R.
- Haraldsson M.
- Fossdal R.
- Thorgeirsson T. E.
- Thorsteinsdottir U.
- Franke B.
- Strengman E.
- Kiemeney L. A.
- Group
- Melle I.
- Djurovic S.
- Abramova I.
- Kaleda V.
- Sanjuan J.
- de Frutos R.
- Bramon E.
- Vassos E.
- Fraser G.
- Ettinger U.
- Picchioni M.
- Walker N.
- Toulopoulou T.
- Need A. C.
- Ge D.
- Lim Yoon J.
- Shianna K. V.
- Freimer N. B.
- Cator R. M.
- Murray R.
- Kong A.
- Golimbet V.
- Carracedo A.
- Arango C.
- Costas J.
- Jonsson E. G.
- Terenius L.
- Agartz I.
- Petursson H.
- Nothen M. M.
- Rietschel M.
- Matthews P. M.
- Muglia P.
- Peltonen L.
- St Clair D.
- Goldstein D. B.
- Stefansson H.
- Collier D.
- Genetic Risk
- Outcome in Psychosis
- Kahn R. S.
- Linszen D. H.
- Van Os J.
- Wiersma D.
- Bruggeman R.
- Cahn H.
- de Haan L.
- Krabbendam L.
- Myin Germeys I.
- RUGGERI, Mirella
- TOSATO, Sarah
DOIAbstract
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative risk of schizophrenia but also of other psychiatric di...
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