Human liver peroxisomal alanine:glyoxylate aminotransferase (AGT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that converts glyoxylate into glycine. AGT deficiency causes primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder, due to a marked increase in hepatic oxalate production. Normal human AGT exists as two polymorphic variants: the major (AGT-Ma) and the minor (AGT-Mi) allele. AGT-Mi causes the PH1 disease only when combined with some mutations. In this study, the molecular basis of the synergism between AGT-Mi and F152I mutation has been investigated through a detailed biochemical characterization of AGT-Mi and the Phe(152) variants combined either with the major (F152I-Ma, F152A-Ma) or the minor allele (F152I...
Alanine:glyoxylate aminotransferase (AGT) is a pyridoxal-phosphate (PLP)-dependent enzyme. Its defic...
AbstractPrimary Hyperoxaluria Type I (PH1) is a severe rare disorder of metabolism due to inherited ...
Primary Hyperoxaluria type I (PH1) is a rare disease due to the deficit of peroxisomal alanine:glyox...
Human liver peroxisomal alanine:glyoxylate aminotransferase (AGT) is a pyridoxal 5'-phosphate (PLP)-...
Human hepatic peroxisomal AGT (alanine:glyoxylate aminotransferase) is a PLP (pyridoxal 5'-phosphate...
The substitution of Ser187, a residue located far from the active site of human liver peroxisomal al...
Liver peroxisomal alanine:glyoxylate aminotransferase (AGT) (EC 2.6.1.44) catalyses the conversion o...
Primary Hyperoxaluria Type I (PH1) is a disorder of glyoxylate metabolism caused by mutations in the...
Liver peroxisomal alanine:glyoxylate aminotransferase (AGT), a pyridoxal 5'-phosphate (PLP) enzyme, ...
Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder of glyoxylate metabolism c...
Primary hyperoxaluria type I (PH1) is a rare disease caused by the deficit of liver alanine-glyoxyla...
His-tagging is commonly used to aid and expedite the purification of recombinant proteins. It is com...
Primary Hyperoxaluria Type I (PH1) is a severe rare disorder of metabolism due to inherited mutation...
16 pags, 5 figsAlanine-glyoxylate aminotransferase catalyzes the transamination between L-alanine an...
In this work the dimerization process of the minor allelic form of human alanine glyoxylate aminotra...
Alanine:glyoxylate aminotransferase (AGT) is a pyridoxal-phosphate (PLP)-dependent enzyme. Its defic...
AbstractPrimary Hyperoxaluria Type I (PH1) is a severe rare disorder of metabolism due to inherited ...
Primary Hyperoxaluria type I (PH1) is a rare disease due to the deficit of peroxisomal alanine:glyox...
Human liver peroxisomal alanine:glyoxylate aminotransferase (AGT) is a pyridoxal 5'-phosphate (PLP)-...
Human hepatic peroxisomal AGT (alanine:glyoxylate aminotransferase) is a PLP (pyridoxal 5'-phosphate...
The substitution of Ser187, a residue located far from the active site of human liver peroxisomal al...
Liver peroxisomal alanine:glyoxylate aminotransferase (AGT) (EC 2.6.1.44) catalyses the conversion o...
Primary Hyperoxaluria Type I (PH1) is a disorder of glyoxylate metabolism caused by mutations in the...
Liver peroxisomal alanine:glyoxylate aminotransferase (AGT), a pyridoxal 5'-phosphate (PLP) enzyme, ...
Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder of glyoxylate metabolism c...
Primary hyperoxaluria type I (PH1) is a rare disease caused by the deficit of liver alanine-glyoxyla...
His-tagging is commonly used to aid and expedite the purification of recombinant proteins. It is com...
Primary Hyperoxaluria Type I (PH1) is a severe rare disorder of metabolism due to inherited mutation...
16 pags, 5 figsAlanine-glyoxylate aminotransferase catalyzes the transamination between L-alanine an...
In this work the dimerization process of the minor allelic form of human alanine glyoxylate aminotra...
Alanine:glyoxylate aminotransferase (AGT) is a pyridoxal-phosphate (PLP)-dependent enzyme. Its defic...
AbstractPrimary Hyperoxaluria Type I (PH1) is a severe rare disorder of metabolism due to inherited ...
Primary Hyperoxaluria type I (PH1) is a rare disease due to the deficit of peroxisomal alanine:glyox...