Bone marrow (BM)-derived mesenchymal stem cells (MSCs) are multipotent, nonhemopoietic progenitors that also possess regulatory activity on immune effector cells through different mechanisms. We demonstrate that human BM-derived MSCs expressed high levels of Toll-like receptors (TLRs) 3 and 4, which are both functional, as shown by the ability of their ligands to induce nuclear factor kappaB (NF-kappaB) activity, as well as the production of interleukin (IL)-6, IL-8, and CXCL10. Of note, ligation of TLR3 and TLR4 on MSCs also inhibited the ability of these cells to suppress the proliferation of T cells, without influencing their immunophenotype or differentiation potential. The TLR triggering effects appeared to be related to the impairment...
SummaryToll-like receptors (TLRs) are best known for their ability to recognize microbial or viral c...
Background and objectives: Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-b...
AbstractMesenchymal stem cells (MSCs) can be polarized into two distinct populations, MSC1 and MSC2,...
BACKGROUND AND OBJECTIVES: Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-b...
Mesenchymal stem cells (MSCs) are wide-spread in adult organisms and may be involved in tissue maint...
Adult human bone marrow-derived mesenchymal stem cells (hMSCs) are under study as therapeutic delive...
Bone marrow-derived mesenchymal stromal cells (BM-MSC) are stromal precursors endowed with extensive...
Adult human bone marrow-derived mesenchymal stem cells (hMSCs) are under study as therapeutic delive...
AbstractMesenchymal stem cells (MSCs) can be polarized into two distinct populations, MSC1 and MSC2,...
Mesenchymal stem cells (MSCs) are of special interest as therapeutic agents in the settings of both ...
In the last decade, the immunomodulatory properties of mesenchymal stromal cells (MSCs) have attract...
Immunosuppressive properties of mesenchymal stem cells (MSCs) offer potential tools for cell-based r...
Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great poten...
.After isolating hTMSCs from discarded inferior turbinate tissue, FACS analysis was used to assess t...
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are known to trigger an innate immune respo...
SummaryToll-like receptors (TLRs) are best known for their ability to recognize microbial or viral c...
Background and objectives: Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-b...
AbstractMesenchymal stem cells (MSCs) can be polarized into two distinct populations, MSC1 and MSC2,...
BACKGROUND AND OBJECTIVES: Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-b...
Mesenchymal stem cells (MSCs) are wide-spread in adult organisms and may be involved in tissue maint...
Adult human bone marrow-derived mesenchymal stem cells (hMSCs) are under study as therapeutic delive...
Bone marrow-derived mesenchymal stromal cells (BM-MSC) are stromal precursors endowed with extensive...
Adult human bone marrow-derived mesenchymal stem cells (hMSCs) are under study as therapeutic delive...
AbstractMesenchymal stem cells (MSCs) can be polarized into two distinct populations, MSC1 and MSC2,...
Mesenchymal stem cells (MSCs) are of special interest as therapeutic agents in the settings of both ...
In the last decade, the immunomodulatory properties of mesenchymal stromal cells (MSCs) have attract...
Immunosuppressive properties of mesenchymal stem cells (MSCs) offer potential tools for cell-based r...
Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great poten...
.After isolating hTMSCs from discarded inferior turbinate tissue, FACS analysis was used to assess t...
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are known to trigger an innate immune respo...
SummaryToll-like receptors (TLRs) are best known for their ability to recognize microbial or viral c...
Background and objectives: Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-b...
AbstractMesenchymal stem cells (MSCs) can be polarized into two distinct populations, MSC1 and MSC2,...