The relationship between the (VO2)-O-. Slow component, muscle metabolites and performance during very-heavy exhaustive exercise

This study examined the relationship between the V O(2) response, particularly the slow component (SC), muscle metabolite changes and performance during very-heavy exhaustive exercise. Sixteen active females performed a graded exercise test to determine V O(2peak) and the lactate threshold followed 48h later by a constant-load cycle test to exhaustion (ET) at 85% V O(2peak) intensity. Muscle biopsies and capillary blood samples were obtained before and after the ET to determine changes in muscle ATP, pH, lactate and phosphocreatine and also plasma pH and lactate. Breath-by-breath data from the ET were smoothed using 5-s averages and fit to a three-component exponential model. The mean time to exhaustion (t(exh)) during the ET was 16.8 (+/-6.4) min. Results showed no correlation between the SC and t(exh) or any muscle metabolite changes (p>0.05). Significant correlations (p<0.05) were evident between t(exh) and tau; tau(0) (r=-0.54), tau(1) (r=-0.65), change in (Delta) pH(b) (r=-0.60), Delta[La(-)](b) (r=-0.58) and [La(-)](b post) (r=-0.64). Significant correlations (p