In a search for highly polymorphic X-specific loci, the X-chromosome DOE Ch35 phage library (LAOXNL01) was screened with three oligonucleotides representative of minisatellite consensus sequences. A total of 170 clones containing human inserts were isolated by hybridization to the oligonucleotide sequences; each was tested for polymorphism on five random female DNAs with six restriction enzymes. Among the 53 clones demonstrating a polymorphic pattern, 47 were of distinct origin. Twelve of the polymorphisms (23%) were determined to be autosomal. Polymorphisms for the remaining 35 clones were characterized, These polymorphisms represent 33 new X-chromosome RFLP loci, since two pairs of clones detected partially overlapping patterns. A pattern...
The cytological location of six cloned DNA sequences on the human X chromosome has been determined t...
The availability of a variety of restriction endonuclease enzymes that cleave deoxyribonucleic acid ...
A rapid screening procedure for restriction fragment length polymorphisms (RFLPs) is reported. DNA f...
The isolation and characterization of DNA probes which detect RFLPs from a small region of the human...
dissertationThe genetic mapping of many X-linked disease genes has been hindered by the uninformativ...
The X chromosome is probably the most studied of all human chromosomes, in part because more than 11...
Probes for CpG islands were cloned from the distal long arm of the human X chromosome; three of them...
Several genes involved in human genetic diseases map to the Xq22 band on the long arm of the human X...
A somatic cell hybrid line containing only human chromosome 21 on a mouse background has been used a...
During a systematic search for X-specific sequences we isolated a DNA fragment (called G1.3) that hy...
We have Identified and characterized 40 DNA probes detecting restriction fragment length polymorphis...
The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-...
Informative members of more than twenty families with X-linked retinitis pigmentosa have been sample...
Using restriction fragment length polymorphisms (RFLPs) and enzymatic variants between distantly rel...
ii. A human Haelll/AIuI DNA library in lambda bacteriophage Charon 4A, was screened for single-copy ...
The cytological location of six cloned DNA sequences on the human X chromosome has been determined t...
The availability of a variety of restriction endonuclease enzymes that cleave deoxyribonucleic acid ...
A rapid screening procedure for restriction fragment length polymorphisms (RFLPs) is reported. DNA f...
The isolation and characterization of DNA probes which detect RFLPs from a small region of the human...
dissertationThe genetic mapping of many X-linked disease genes has been hindered by the uninformativ...
The X chromosome is probably the most studied of all human chromosomes, in part because more than 11...
Probes for CpG islands were cloned from the distal long arm of the human X chromosome; three of them...
Several genes involved in human genetic diseases map to the Xq22 band on the long arm of the human X...
A somatic cell hybrid line containing only human chromosome 21 on a mouse background has been used a...
During a systematic search for X-specific sequences we isolated a DNA fragment (called G1.3) that hy...
We have Identified and characterized 40 DNA probes detecting restriction fragment length polymorphis...
The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-...
Informative members of more than twenty families with X-linked retinitis pigmentosa have been sample...
Using restriction fragment length polymorphisms (RFLPs) and enzymatic variants between distantly rel...
ii. A human Haelll/AIuI DNA library in lambda bacteriophage Charon 4A, was screened for single-copy ...
The cytological location of six cloned DNA sequences on the human X chromosome has been determined t...
The availability of a variety of restriction endonuclease enzymes that cleave deoxyribonucleic acid ...
A rapid screening procedure for restriction fragment length polymorphisms (RFLPs) is reported. DNA f...