Thirty-five patients with thalassemia major, aged 7 to 21 years, were studied to define the relationship between the pubertal development and the growth-hormone (GH) secretion during sleep, after administration of GH-releasing factor (hpGRF 1-44), and betaxolol-glucagon or arginin-insulin. Pubertal development was classified as being appropriate or delayed for chronological age. GH response to pharmacological stimuli and during sleep was not linked to the pubertal development according to the chronological age. The peak of GH secretion after GHRH injection was significantly delayed in thalassemic patients with retarded puberty. The integrated secretion of GH during the 120-min test was slightly but not significantly reduced in these patient...
The increased survival of patients with thalassemia major, made possible by more adequate therapeuti...
A reduced GH secretion has often been shown in prepubertal children with delays in pubertal developm...
To delineate possible factors influencing the magnitude of the GH response to GH-releasing hormone (...
Thirty-five patients with thalassemia major, aged 7 to 21 years, were studied to define the relation...
The effect of long-term human chorionic gonadotropin (HCG) therapy on the linear growth and biologic...
The response of GH to acute administration of GH-releasing hormone (GHRH) was evaluated in 19 patien...
Background: Present transfusion protocols have increased the life expectancy of patients with β-thal...
Endocrine dysfunction in Thalassaemia major (TM) is a common and disturbing complication, which requ...
Gonadotrophin-hormone-releasing-hormone-Gonadotrophin hormone (GnRH-GTH) secretory dynamics of 30 fe...
In patients with b-thalassemia major (TM), the anterior pituitary gland is particularly sensitive to...
Objective - Impairment of linear growth is a common clinical feature in patients with \u3b2-thalassa...
Background. In the last years thalassemic patients gained a good improvement in prognosis and life s...
Introduction: Thalassemia Major Illness is mainly created as a progressive hemolytic anemia within t...
GH responsiveness to insulin-induced hypoglycaemia and its circadian secretion were studied in a gro...
Methodology: A cross-sectional study of growth, puberty and endocrine function was performed on 35 g...
The increased survival of patients with thalassemia major, made possible by more adequate therapeuti...
A reduced GH secretion has often been shown in prepubertal children with delays in pubertal developm...
To delineate possible factors influencing the magnitude of the GH response to GH-releasing hormone (...
Thirty-five patients with thalassemia major, aged 7 to 21 years, were studied to define the relation...
The effect of long-term human chorionic gonadotropin (HCG) therapy on the linear growth and biologic...
The response of GH to acute administration of GH-releasing hormone (GHRH) was evaluated in 19 patien...
Background: Present transfusion protocols have increased the life expectancy of patients with β-thal...
Endocrine dysfunction in Thalassaemia major (TM) is a common and disturbing complication, which requ...
Gonadotrophin-hormone-releasing-hormone-Gonadotrophin hormone (GnRH-GTH) secretory dynamics of 30 fe...
In patients with b-thalassemia major (TM), the anterior pituitary gland is particularly sensitive to...
Objective - Impairment of linear growth is a common clinical feature in patients with \u3b2-thalassa...
Background. In the last years thalassemic patients gained a good improvement in prognosis and life s...
Introduction: Thalassemia Major Illness is mainly created as a progressive hemolytic anemia within t...
GH responsiveness to insulin-induced hypoglycaemia and its circadian secretion were studied in a gro...
Methodology: A cross-sectional study of growth, puberty and endocrine function was performed on 35 g...
The increased survival of patients with thalassemia major, made possible by more adequate therapeuti...
A reduced GH secretion has often been shown in prepubertal children with delays in pubertal developm...
To delineate possible factors influencing the magnitude of the GH response to GH-releasing hormone (...