Naproxen and its derivative nitronaproxen at the doses of 5 and 10 mg kg-1 were compared for their acute anti-inflammatory efficacy in a carrageenan oedema model and gastrointestinal toxicity in rats. Moreover, the effects of the two drugs were evaluated in the adjuvant arthritis, after chronic doses of 4 and 8 mg kg-1 administered orally for 18 days. The oedema reduction was maintained much longer (until 5 h) with nitronaproxen; the inhibition of arthritis was 50% or more with both doses of the examined drugs. From the histological examination of the stomachs, an extensive mucosal vasocongestion and haemorrhagic lesions have been observed in some rats treated with naproxen. The percentages of animals with ulcers were 50, 100 and 10 with na...
Nonsteroidal anti-inflammatory drugs (NSAIDs) have well-characterized inhibitory effects on gastric ...
This is a comparative study of anti-inflammatory effect of two synthetic compounds, due to their s...
ABSTRACT: Naproxen and its synthesized esters namely naproxen methyl ester, C15H16O3 (compound 1), e...
Background/Aims: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their abilit...
Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-coun...
BACKGROUND: Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents fo...
Addition of a nitroxybutyl moiety to diclofenac greatly reduces its damaging effects on the gastric ...
Background and purpose: Hydrogen sulphide is an important mediator of gastric mucosal defence. The u...
In this study, we assessed the effects of addition of a nitroxybutyl moiety to diclofenac on its ulc...
1. Anti-inflammatory non steroidal drugs releasing NO (NO-NSAIDs) are a new class of anti-inflammato...
<p>Despite comparable suppression of paw swelling (panel A), gastric prostaglandin synthesis (panel ...
Nonsteroidal anti-inflammatory drugs (NSAIDs) have well-characterized inhibitory effects on gastric ...
This is a comparative study of anti-inflammatory effect of two synthetic compounds, due to their s...
ABSTRACT: Naproxen and its synthesized esters namely naproxen methyl ester, C15H16O3 (compound 1), e...
Background/Aims: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their abilit...
Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-coun...
BACKGROUND: Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents fo...
Addition of a nitroxybutyl moiety to diclofenac greatly reduces its damaging effects on the gastric ...
Background and purpose: Hydrogen sulphide is an important mediator of gastric mucosal defence. The u...
In this study, we assessed the effects of addition of a nitroxybutyl moiety to diclofenac on its ulc...
1. Anti-inflammatory non steroidal drugs releasing NO (NO-NSAIDs) are a new class of anti-inflammato...
<p>Despite comparable suppression of paw swelling (panel A), gastric prostaglandin synthesis (panel ...
Nonsteroidal anti-inflammatory drugs (NSAIDs) have well-characterized inhibitory effects on gastric ...
This is a comparative study of anti-inflammatory effect of two synthetic compounds, due to their s...
ABSTRACT: Naproxen and its synthesized esters namely naproxen methyl ester, C15H16O3 (compound 1), e...