Comparison of the Effects of Two Oat-based Cereals on Appetite and Satiety, and the Effect of a Fat Emulsion of Appetite, Satiety, Food Intake, and Body Weight

The objective of these studies was to investigate the satiety effects of foods typically consumed as part of a breakfast meal, and a novel fat emulsion designed to stimulate satiety signals. The first study compared the satiety effects of oatmeal with a popular ready-to-eat breakfast cereal (RTEC). The second study assessed the effects of the fat emulsion Olibra¢â, on satiety, food intake, and body weight. Forty-eight healthy individuals, ¡Ã18 years of age were enrolled in a randomized controlled crossover trial. Following an overnight fast, subjects consumed either oatmeal or RTEC in random order at least a week apart. Visual analogue scales (VAS) of appetite and satiety were completed at baseline, and 30, 60, 120, 180 and 240 minutes postprandial. Appetite and satiety scores were analyzed by area under the curve (AUC) assessed across the time-points. Oatmeal, resulted in greater increase in fullness (AUC: p=0.005 [120min: p=0.0408, 180min: p=0.0061, 240min: p=0.0102]) than the RTEC. Hunger (AUC: p=0.0009 [120min: p=0.0197, 180min: p=0.0003, 240min: p=0.0036]), desire to eat (AUC: p=0.0002 [120min: p=0.0168, 180min: p\u3c0.0001, 240min: p=0.0022]), and prospective intake (AUC: p=0.0012 [120min: p=0.0058, 180min: p=0.006, 240min: p=0.0047]) decreased to a greater extent with oatmeal as compared with the RTEC. In the study investigating Olibra¢â, 82 subjects (18-60 years of age, body mass index: 25-40 kg/m2) were enrolled in a randomized, placebo-controlled, double-blind, parallel trial. During a 12-week period, the effects of Olibra¢â fat emulsion (2.1g twice daily) on food intake, appetite, satiety, weight, and body composition were compared with those of a twice daily administered placebo (1.95g milk fat). Data relating to 71 subjects were analyzed using analysis of covariance. Differential weight and waist circumference reductions were not significant. Differential group effects were not significant for body fat, waist-hip ratio, food intake, appetite, and satiety. The studies showed that oatmeal increased satiety to a greater extent than the RTEC in the four hour period post-prandial; however, consumption of Olibra¢â had no effect on satiety or food intake. Additionally, daily consumption of Olibra¢â had no effect on body weight or body composition at the end of 12 weeks