Acetylcysteine to prevent Contrast-Induced Acute Kidney Injury

Problem: Contrast-Induced Acute Kidney Injury (CI-AKI) is responsible for 10% of acute kidney injury episodes acquired in hospital patients. And it is the third leading cause of hospital-acquired acute kidney injury and with a mortality rate of 20%. Project: Is to find preventive measures to decreases CI-AKI. Solution: Research has shown that hydration and acetylcysteine (NAC) prior to contrast enhance CT can reduce the incidence of CI-AKI. Using NAC is low cost and ready availability, ease of administration by both the oral route and an intravenous injection with limited side effects. The Goal is to decrease the incidences of CI-AKI after a contrast enhancement CT. The Effectiveness of the solution: NAC is a direct scavenger of free radicals and improves blood flow, which results in vasodilation. As result, both the antioxidant and vasodilatory properties of NAC are believed to protect against CI-AKI. Enough hydration and consumption of drugs with Renoprotective effects can decrease the incidence of CI-AKI Recommendation: Prior to CT with contrast use the normal saline protocol 1.0-1.5ml/kg/hr. at least 6 hours before and add oral NAC with the dose range of 600- 1600mg twice daily of the day before and the day of Contrast CT to prevent CI-AKI