Add to ORKGDNA replication has to be tightly regulated to ensure genome integrity such that DNA replication takes place only once per cell cycle. The Cdc6 sequential phosphorylation by GSK-3 and Cdk1 creates a binding site for Cdc4 ubiquitin ligase to promote Cdc6 degradation
Cells are constantly threatened by multiple sources of genotoxic stress that cause DNA damage. To ma...
The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA rep...
Faithful chromosome segregation maintains chromosomal stability as errors in this process contribute...
DNA replication has to be tightly regulated to ensure genome integrity such that DNA replication tak...
Cdc6p is an essential component of the pre-replicative complex (pre-RC), which binds to DNA replicat...
ABSTRACT To ensure genome integrity, DNA replication takes place only once per cell cycle and is tig...
Control of DNA replication is critical for progression of the cell cycle and genomic stability. Cycl...
The replication initiation protein Cdc6p forms a tight complex with Cdc28p, specifically with forms ...
The Cdc6 protein is an essential component of pre-replication complexes (preRCs), which assemble at ...
In eukaryotes cell proliferation requires the formation of a pre-replication complex (preRC) at chro...
The mammalian cell cycle is regulated by periodic gene transcription, kinase activities and protein ...
AbstractBackground: Cdc28p, the major cyclin-dependent kinase in budding yeast, prevents re-replicat...
Cdc6p has an essential function in the mechanism and regulation of the initiation of DNA replication...
Faithful inheritance of genetic information requires that DNA be copied only once each cell cycle. I...
SummaryCyclin-dependent kinases (CDKs) restrict DNA replication origin firing to once per cell cycle...
Cells are constantly threatened by multiple sources of genotoxic stress that cause DNA damage. To ma...
The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA rep...
Faithful chromosome segregation maintains chromosomal stability as errors in this process contribute...
DNA replication has to be tightly regulated to ensure genome integrity such that DNA replication tak...
Cdc6p is an essential component of the pre-replicative complex (pre-RC), which binds to DNA replicat...
ABSTRACT To ensure genome integrity, DNA replication takes place only once per cell cycle and is tig...
Control of DNA replication is critical for progression of the cell cycle and genomic stability. Cycl...
The replication initiation protein Cdc6p forms a tight complex with Cdc28p, specifically with forms ...
The Cdc6 protein is an essential component of pre-replication complexes (preRCs), which assemble at ...
In eukaryotes cell proliferation requires the formation of a pre-replication complex (preRC) at chro...
The mammalian cell cycle is regulated by periodic gene transcription, kinase activities and protein ...
AbstractBackground: Cdc28p, the major cyclin-dependent kinase in budding yeast, prevents re-replicat...
Cdc6p has an essential function in the mechanism and regulation of the initiation of DNA replication...
Faithful inheritance of genetic information requires that DNA be copied only once each cell cycle. I...
SummaryCyclin-dependent kinases (CDKs) restrict DNA replication origin firing to once per cell cycle...
Cells are constantly threatened by multiple sources of genotoxic stress that cause DNA damage. To ma...
The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA rep...
Faithful chromosome segregation maintains chromosomal stability as errors in this process contribute...