Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. In addition to binding to NMDA receptors, dextromethorphan binds to sigma-1 (s1) receptors, which are believed to be protein targets for a potential new class of antidepressant medications. The purpose of this study was to determine whether dextromethorphan elicits antidepressant-like effects and the involvement of s1 receptors in mediating its antidepressant-like actions. The antidepressant-like effects of dextromethorphan were assessed in male, Swiss Webster mice using the forced swim test. Next, s1 r...
Major depressive disorder (MDD), is a common and severe mood disorder. Globally, ~ 300 million peopl...
[eng] The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondri...
Background A number of σ receptor ligands have been demonstrated to possess antidepressant-like effe...
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to displa...
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to displa...
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to displa...
Depression affects more than 350 million people and is the leading cause of disability worldwide. Ma...
Dextromethorphan (DM) has been used for more than 50 years as an over-the-counter antitussive. Studi...
Depression is a state of low mood that can seriously affect the quality of life of society. Therefor...
Depression is estimated to affect at least 30% of the world\u27s population at some point during the...
AbstractDextromethorphan (DM) has been used for more than 50years as an over-the-counter antitussive...
Behavioural models used to test antidepressants have shown that ligands that bind to sigma receptor...
[[abstract]]Chronic use of morphine causes rewarding and behavioral sensitization, which may lead to...
Accumulating evidence suggests that sigma-1 receptors play a role in the pathophysiology of neuropsy...
Ketamine has been shown to produce rapid and robust antidepressant effects in depressed individuals,...
Major depressive disorder (MDD), is a common and severe mood disorder. Globally, ~ 300 million peopl...
[eng] The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondri...
Background A number of σ receptor ligands have been demonstrated to possess antidepressant-like effe...
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to displa...
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to displa...
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to displa...
Depression affects more than 350 million people and is the leading cause of disability worldwide. Ma...
Dextromethorphan (DM) has been used for more than 50 years as an over-the-counter antitussive. Studi...
Depression is a state of low mood that can seriously affect the quality of life of society. Therefor...
Depression is estimated to affect at least 30% of the world\u27s population at some point during the...
AbstractDextromethorphan (DM) has been used for more than 50years as an over-the-counter antitussive...
Behavioural models used to test antidepressants have shown that ligands that bind to sigma receptor...
[[abstract]]Chronic use of morphine causes rewarding and behavioral sensitization, which may lead to...
Accumulating evidence suggests that sigma-1 receptors play a role in the pathophysiology of neuropsy...
Ketamine has been shown to produce rapid and robust antidepressant effects in depressed individuals,...
Major depressive disorder (MDD), is a common and severe mood disorder. Globally, ~ 300 million peopl...
[eng] The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondri...
Background A number of σ receptor ligands have been demonstrated to possess antidepressant-like effe...