Isotretinoin in the Body

Isotretinoin is the active compound in many generic brand retinoid drugs such as Myorisan. It was originally marketed as Accutane by the pharmaceutical company Hoffman-La Roche after receiving FDA approval in 1982. This drug is a an oral retinoid (vitamin A derivative) used to treat severe acne and occasionally some forms of head and neck cancer. This presentation will explore the discovery of isotretinoin as well as its pharmacokinetic and pharmacodynamic properties. Although the mechanism of reaction is unknown, the presenter attempts to deduce some possible interactions at the binding site by studying and comparing isotretinoin to vitamin A