Advanced DEVS Models With Application to Biomedicine

Simulation is becoming increasingly important in the analysis and design of complex systems such as thoseinvolving biological processes. The complexity of these systems makes computer simulation an adequate tool to study them under particular experimental conditions. We presented a simulation model for the metabolic pathways in the cells (namely, the Glycolysis and Krebs cycle), using the DEVS formalism and the CD++ tool. Here, we extend this experience, and we show a model on synapsin and vesicles interaction in nerve cells, and another one on the liver functions using similar techniques. Our long term goal is to provide realistic simulations of different biological processes when specific internal or external parameters are applied. --From the paper