In the Laboratory of Mechanistic Glycobiology at Michigan Technological University, we have been working in four distinct but related areas. Our findings can significantly influence human health-related research. (1) We have documented a molecular strategy that can improve drug designing. (2) We have shown that the tumor-associated protein galectin-3 can create problems in cancer biomarker assays by hiding the biomarkers. (3) In another project, we reported that the role of galectin-3 in cancer could be more complicated than what is reported in the literature. (4) Our team also detected a novel natural product with anti-fungal and anti-cancer activities.https://digitalcommons.mtu.edu/techtalks/1012/thumbnail.jp
Cell surfaces feature abundant glycosylation. Glycans adorn roughly 90% of cell surface proteins and...
Glycosylation involves the post-translational addition of carbohydrates to protein molecules and is ...
Many of the biopharmaceutical therapeutics entering the market and currently in clinical trails are ...
Thyroid cancer is the most common endocrine carcinoma. Currently, the clinical diagnosis of thyroid ...
A near universal feature of virtually every major disease in humans has been the observation that pr...
Changes in glycosylation have long been appreciated to be part of the cancer phenotype; sialylated g...
Kohlenhydrat-Protein-Wechselwirkungen sind häufig entscheidend beteiligt an verschiedenen einer Infe...
Glycans are central to many biological processes, but efforts to define their functions at the molec...
Glycosylation is one of the most prevalent post-translational modifications found on biomolecules th...
Aberrant glycosylation in cancer cells can often lead to an increase in the exposure of unusual gly...
Glycans are highly complex carbohydrate molecules and, unlike proteins, they are not encoded by the ...
In the post-genomic era, many efforts have been devoted to better understanding the biological infor...
Paramount to our understanding of carbohydrates in biology has been the development of methods for a...
Locating at the outer surface of cells, glycans and their glycoconjugates play multitude of roles in...
A complex physiological culture medium (Plasmax) was introduced recently, composed of nutrients and ...
Cell surfaces feature abundant glycosylation. Glycans adorn roughly 90% of cell surface proteins and...
Glycosylation involves the post-translational addition of carbohydrates to protein molecules and is ...
Many of the biopharmaceutical therapeutics entering the market and currently in clinical trails are ...
Thyroid cancer is the most common endocrine carcinoma. Currently, the clinical diagnosis of thyroid ...
A near universal feature of virtually every major disease in humans has been the observation that pr...
Changes in glycosylation have long been appreciated to be part of the cancer phenotype; sialylated g...
Kohlenhydrat-Protein-Wechselwirkungen sind häufig entscheidend beteiligt an verschiedenen einer Infe...
Glycans are central to many biological processes, but efforts to define their functions at the molec...
Glycosylation is one of the most prevalent post-translational modifications found on biomolecules th...
Aberrant glycosylation in cancer cells can often lead to an increase in the exposure of unusual gly...
Glycans are highly complex carbohydrate molecules and, unlike proteins, they are not encoded by the ...
In the post-genomic era, many efforts have been devoted to better understanding the biological infor...
Paramount to our understanding of carbohydrates in biology has been the development of methods for a...
Locating at the outer surface of cells, glycans and their glycoconjugates play multitude of roles in...
A complex physiological culture medium (Plasmax) was introduced recently, composed of nutrients and ...
Cell surfaces feature abundant glycosylation. Glycans adorn roughly 90% of cell surface proteins and...
Glycosylation involves the post-translational addition of carbohydrates to protein molecules and is ...
Many of the biopharmaceutical therapeutics entering the market and currently in clinical trails are ...