Add to ORKGA series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell proliferation activities were evaluated with a long-term estrogen deprived MCF-7aro (LTEDaro) breast cancer cell line, which is the biological model of aromatase inhibitor resistance for hormone-dependent breast cancer. Compared to nimesulide which inhibited LTEDaro cell proliferation with an IC50 at 170.30 μM, several new compounds showed IC50 close to 1.0 μM
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer ...
Aromatase is a particularly attractive drug target in the treatment of hormone-responsive breast can...
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment o...
A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell proli...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide derivatives compounds A and B decreased aromatase acti...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide derivatives compounds A and B decreased aromatase acti...
Epidemiological and animal model studies have suggested that non-steroidal anti-inflammatory drugs (...
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment o...
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment o...
Epidemiological and animal model studies have suggested that non-steroidal anti-inflammatory drugs (...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer ...
JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent ...
Non-steroidal anti inflammatory drugs which were primarily used for the treatment inflammation and p...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer ...
Previous studies have demonstrated that cyclooxygenase-2 (COX-2) inhibitor NS-398 decrease aromatase...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer ...
Aromatase is a particularly attractive drug target in the treatment of hormone-responsive breast can...
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment o...
A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell proli...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide derivatives compounds A and B decreased aromatase acti...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide derivatives compounds A and B decreased aromatase acti...
Epidemiological and animal model studies have suggested that non-steroidal anti-inflammatory drugs (...
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment o...
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment o...
Epidemiological and animal model studies have suggested that non-steroidal anti-inflammatory drugs (...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer ...
JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent ...
Non-steroidal anti inflammatory drugs which were primarily used for the treatment inflammation and p...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer ...
Previous studies have demonstrated that cyclooxygenase-2 (COX-2) inhibitor NS-398 decrease aromatase...
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer ...
Aromatase is a particularly attractive drug target in the treatment of hormone-responsive breast can...
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment o...