Silaic acid is the most common terminal glycan on cell surface glycoproteins and glycolipids, involving in many biological processes. Studying interactions between multivalent sialic acid scaffolds and proteins binding to it will give incredible information in understanding the biological process the sialic acid is involved in. Here we describe chemoenzymatic synthesis of chain-end functionalized sialyllactose-containing glycopolymers with different linkages and their oriented immobilization for glycoarray and SPR-based glyco-biosensor applications
Abnormal sialylation of proteins is highly associated with many major diseases, such as cancers and ...
Les glycannes, présents chez tous les êtres vivants forment une des grandes classes de biomolécules...
Glycan microarray has become a powerful high-throughput tool for examining binding interactions of c...
Silaic acid is the most common terminal glycan on cell surface glycoproteins and glycolipids, involv...
We report a chemoenzymatic synthesis of chain-end functionalized sialyllactose-containing glycopolym...
Four glycodendrons and a glycocluster were synthesized from carbohydrate building blocks to form pau...
Glycans have been shown to play a key role in many biological processes, such as signal transduction...
The metabolic oligosaccharide engineering (MOE) strategy using unnatural sialic acids has recently e...
Sialic acids (Sias) are a group of α-keto acids with a nine-carbon backbone, which display many type...
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners...
We report an oriented glyco-macroligand formation and its glyco-affinity capturing and glycoarray ap...
Sialic acid analogues containing a unique chemical functionality or chemical reporter have been meta...
Sialooligosaccharides were generated by direct enzymatic glycosylation on arrays and the resulting s...
Sialic acid analogues containing a unique chemical functionality or chemical reporter have been meta...
Glycosylation plays an important role in various pathological processes such as cancer. One key alte...
Abnormal sialylation of proteins is highly associated with many major diseases, such as cancers and ...
Les glycannes, présents chez tous les êtres vivants forment une des grandes classes de biomolécules...
Glycan microarray has become a powerful high-throughput tool for examining binding interactions of c...
Silaic acid is the most common terminal glycan on cell surface glycoproteins and glycolipids, involv...
We report a chemoenzymatic synthesis of chain-end functionalized sialyllactose-containing glycopolym...
Four glycodendrons and a glycocluster were synthesized from carbohydrate building blocks to form pau...
Glycans have been shown to play a key role in many biological processes, such as signal transduction...
The metabolic oligosaccharide engineering (MOE) strategy using unnatural sialic acids has recently e...
Sialic acids (Sias) are a group of α-keto acids with a nine-carbon backbone, which display many type...
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners...
We report an oriented glyco-macroligand formation and its glyco-affinity capturing and glycoarray ap...
Sialic acid analogues containing a unique chemical functionality or chemical reporter have been meta...
Sialooligosaccharides were generated by direct enzymatic glycosylation on arrays and the resulting s...
Sialic acid analogues containing a unique chemical functionality or chemical reporter have been meta...
Glycosylation plays an important role in various pathological processes such as cancer. One key alte...
Abnormal sialylation of proteins is highly associated with many major diseases, such as cancers and ...
Les glycannes, présents chez tous les êtres vivants forment une des grandes classes de biomolécules...
Glycan microarray has become a powerful high-throughput tool for examining binding interactions of c...