Cell division is critically important in human development and disease (e.g., cancer). Numerous proteins regulate cell division, and two protein complexes, SCF (SKP1/CUL-1/F-box protein) and APC/C (anaphase-promoting complex/ cyclosome), control degradation of some of these proteins. These complexes also regulate the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, and glutaminase 1, the enzyme that initiates glutamine breakdown. SCF and APC/C utilize ubiquitin, a protein that targets regulatory proteins for degradation using specific amino acids sequences called degradation motifs. Our discovery that SCF and APC/C use the same degradation motifs for regulating metabolism and cell division provides an import...
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of...
© 2014 Lu et al.The ubiquitin protein ligase anaphase-promoting complex or cyclosome (APC/C) control...
AbstractWe have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mut...
Cell division is critically important in human development and disease (e.g., cancer). Numerous prot...
AbstractRegulated protein degradation has emerged as a key recurring theme in multiple aspects of ce...
Coordination of events required for cell cycle progression is orchestrated in large part by the ubiq...
The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itsel...
For correct cell division to take place, many different mechanisms ensure genomic integrity and form...
Proteolysis of cell cycle regulators is essential for transit through the cell cycle. Much of this ...
AbstractTwo families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the ...
The SKP1, CUL1, F-box protein (SCF) complex encompasses a group of 69 SCF E3 ubiquitin ligase comple...
Using multiplexed quantitative proteomics, we analyzed cell cycle-dependent changes of the human pro...
SummaryProper cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key r...
In the process of carcinogenesis, abnormal regulation of cell cycle regulators is essential. Cell cy...
Proper cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key regulato...
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of...
© 2014 Lu et al.The ubiquitin protein ligase anaphase-promoting complex or cyclosome (APC/C) control...
AbstractWe have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mut...
Cell division is critically important in human development and disease (e.g., cancer). Numerous prot...
AbstractRegulated protein degradation has emerged as a key recurring theme in multiple aspects of ce...
Coordination of events required for cell cycle progression is orchestrated in large part by the ubiq...
The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itsel...
For correct cell division to take place, many different mechanisms ensure genomic integrity and form...
Proteolysis of cell cycle regulators is essential for transit through the cell cycle. Much of this ...
AbstractTwo families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the ...
The SKP1, CUL1, F-box protein (SCF) complex encompasses a group of 69 SCF E3 ubiquitin ligase comple...
Using multiplexed quantitative proteomics, we analyzed cell cycle-dependent changes of the human pro...
SummaryProper cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key r...
In the process of carcinogenesis, abnormal regulation of cell cycle regulators is essential. Cell cy...
Proper cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key regulato...
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of...
© 2014 Lu et al.The ubiquitin protein ligase anaphase-promoting complex or cyclosome (APC/C) control...
AbstractWe have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mut...