Summarization: It is known that ball milling is an energy intensive process and great efforts have been made over the years to improve energy efficiency. The use of population balance models (PBMs) can assist in the design of mineral processing circuits and the scale-up of laboratory mill results to full-scale. However, since each model has its own capabilities and limitations, it is believed that a combined use will provide more accurate information for the reliable description of the process. In this study, the simulation of grinding of quartz is investigated in order to identify the optimal mill operating parameters. With the use of population balance modeling the specific rate of breakage and the cumulative breakage parameters can be de...