Topics
histone acetyltransferaseBiomolecule
Mucoepidermoid carcinomaDisease
biologyWork
CisplatinChemical substance
phenotypeHistoric place
chemotherapyTelevision station
Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The response of MEC to chemotherapy is unpredictable, and recent advances in cancer biology suggest the involvement of cancer stem cells (CSCs) in tumor progression and chemoresistance and radioresistance phenotype. We found that histone acetyltransferase inhibitors (HDACi) were capable of disrupting CSCs in MEC. Furthermore, administration of HDACi prior to Cisplatin (two-hit approach) disrupts CSCs and sensitizes tumor cells to Cisplatin. Our findings corroborate to emerging evidence that CSCs play a key role in tumor resistance to chemotherapy, and highlights a pharmacological two-hit approach that disrupts tumor resistance to conventional therapy
Resistance to cancer therapy remains a significant obstacle in treating patients with various solid ...
BACKGROUND: Treatment failure in oral squamous cell carcinoma (OSCC) leading to local recurrence(s) ...
Despite scientific advances in the Oncology field, cancer remains a leading cause of death worldwide...
Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The response of MEC...
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Mucoepidermoid carcinoma (MEC) is...
Malignancies from the salivary glands are rare and represent 11% of all cancers from the oropharynge...
Adenoid cystic carcinoma (ACC) is an uncommonmalignancy of the salivary glands that is characterized...
The genome is organized and packed into the nucleus through interactions with core histone proteins....
The genome is organized and packed into the nucleus through interactions with core histone proteins....
Cancer lethality is mainly due to the onset of distant metastases and refractoriness to chemotherapy...
Cancer stem cells (CSCs) are tumor initiating cells within the tumor mass; that play a critical role...
Cancer stem cells are found in many cancer types. They comprise a distinct subpopulation of cells wi...
Head and neck cancers are often diagnosed at later stages with poor outcomes. Mesenchymal stem cells...
Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resi...
Cancer stem cells (CSCs), or tumor-initiating cells, are a small subset of cancer cells with the cap...
Resistance to cancer therapy remains a significant obstacle in treating patients with various solid ...
BACKGROUND: Treatment failure in oral squamous cell carcinoma (OSCC) leading to local recurrence(s) ...
Despite scientific advances in the Oncology field, cancer remains a leading cause of death worldwide...
Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The response of MEC...
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Mucoepidermoid carcinoma (MEC) is...
Malignancies from the salivary glands are rare and represent 11% of all cancers from the oropharynge...
Adenoid cystic carcinoma (ACC) is an uncommonmalignancy of the salivary glands that is characterized...
The genome is organized and packed into the nucleus through interactions with core histone proteins....
The genome is organized and packed into the nucleus through interactions with core histone proteins....
Cancer lethality is mainly due to the onset of distant metastases and refractoriness to chemotherapy...
Cancer stem cells (CSCs) are tumor initiating cells within the tumor mass; that play a critical role...
Cancer stem cells are found in many cancer types. They comprise a distinct subpopulation of cells wi...
Head and neck cancers are often diagnosed at later stages with poor outcomes. Mesenchymal stem cells...
Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resi...
Cancer stem cells (CSCs), or tumor-initiating cells, are a small subset of cancer cells with the cap...
Resistance to cancer therapy remains a significant obstacle in treating patients with various solid ...
BACKGROUND: Treatment failure in oral squamous cell carcinoma (OSCC) leading to local recurrence(s) ...
Despite scientific advances in the Oncology field, cancer remains a leading cause of death worldwide...
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