The cell-mediated mutation system, with the proper choice of metabolizing cells, can be used to detect the mutagenic activities of different classes of chemical carcinogens. When fibroblastic cells were used as the metabolizing cells, a correlation between the in vivo carcinogenic activity and the in vitro mutagenic activity of 11 aromatic polycyclic hydrocarbons was observed. When primary liver cells were used as the metabolizing cells, three known liver carcinogens were demonstrated to be mutagenic by the cell-mediated assay, while two non-carcinogenic analogues were not mutagenic. These results from the cell-mediated system suggest that the reactive intermediates of the carcinogens are stable enough to be transferred from the metabolizin...
In order to analyze the adducts formed in V79 Chinese hamster target cells in a Syrian hamster embry...
To develop an improved in vitro mammalian cell gene mutation assay, it is imperative to address the ...
As demonstrated in Part I, cultured MutaMouse primary hepatocytes (PHs) are suitable cells for use i...
Results are reported from studies that showed that mutagenesis of mammalian cells can be achieved by...
A liver and lung cell-mediated-V79 cell mutagenesis system using intact cells as metabolic activatio...
We present here the results obtained within the framework of an EU funded project aimed to develop a...
We present here the results obtained within the framework of an EU funded project aimed to develop a...
The metabolic capacity to activate the indirectly acting promutagens aflatoxin Bl, cyclophosphamide,...
The metabolic capacity to activate the indirectly acting promutagens aflatoxin B1, cyclophosphamide,...
SUMMARY-Over 30 polycyclic hydrocarbons, azo dyes, aromatic amines, and miscellaneous chemicals were...
In the context of the somatic mutation theory of chemical carcinogenesis, mutations are thought to a...
In order to analyze the adducts formed in V79 Chinese hamster target cells in a Syrian hamster embry...
In order to analyze the adducts formed in V79 Chinese hamster target cells in a Syrian hamster embry...
To develop an improved in vitro mammalian cell gene mutation assay, it is imperative to address the ...
The development of in vitro test systems for evaluating the toxic, mutagenic, and carcinogenic poten...
In order to analyze the adducts formed in V79 Chinese hamster target cells in a Syrian hamster embry...
To develop an improved in vitro mammalian cell gene mutation assay, it is imperative to address the ...
As demonstrated in Part I, cultured MutaMouse primary hepatocytes (PHs) are suitable cells for use i...
Results are reported from studies that showed that mutagenesis of mammalian cells can be achieved by...
A liver and lung cell-mediated-V79 cell mutagenesis system using intact cells as metabolic activatio...
We present here the results obtained within the framework of an EU funded project aimed to develop a...
We present here the results obtained within the framework of an EU funded project aimed to develop a...
The metabolic capacity to activate the indirectly acting promutagens aflatoxin Bl, cyclophosphamide,...
The metabolic capacity to activate the indirectly acting promutagens aflatoxin B1, cyclophosphamide,...
SUMMARY-Over 30 polycyclic hydrocarbons, azo dyes, aromatic amines, and miscellaneous chemicals were...
In the context of the somatic mutation theory of chemical carcinogenesis, mutations are thought to a...
In order to analyze the adducts formed in V79 Chinese hamster target cells in a Syrian hamster embry...
In order to analyze the adducts formed in V79 Chinese hamster target cells in a Syrian hamster embry...
To develop an improved in vitro mammalian cell gene mutation assay, it is imperative to address the ...
The development of in vitro test systems for evaluating the toxic, mutagenic, and carcinogenic poten...
In order to analyze the adducts formed in V79 Chinese hamster target cells in a Syrian hamster embry...
To develop an improved in vitro mammalian cell gene mutation assay, it is imperative to address the ...
As demonstrated in Part I, cultured MutaMouse primary hepatocytes (PHs) are suitable cells for use i...